ReviewJournal of oral & maxillofacial research
Surgical Regenerative Treatments for Peri-Implantitis: Meta-analysis of Recent Findings in a Systematic Literature Review.
Review in Journal of oral & maxillofacial research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 66 citations in OpenAlex.
- Efficacy of concentrated growth factor versus collagen membrane in reconstructive surgical therapy of peri-implantitis: 3-year results of a randomized clinical trial.Clinical oral investigations · 2022Trial
- Surgical and non-surgical debridement for the treatment of peri-implantitis: a two-center 12-month randomized trial.Clinical oral investigations · 2021Trial
- Regenerative Surgical Treatment of Peri-Implantitis: A Systematic Review and Meta-Analysis.Dentistry journal · 2026Review
- Adjunctive effect of soft tissue grafting in the surgical treatment of peri-implantitis: clinical and radiographic outcomes from a preclinical canine experiment.Journal of periodontal & implant science · 2026Article
- Evaluating the Clinical Efficacy of Membrane-Assisted Regenerative Therapy in Peri-Implantitis Management: A Comprehensive Review Incorporating Systematic Review Evidence.Materials (Basel, Switzerland) · 2025Review
- Autologous and Heterologous Minor and Major Bone Regeneration with Platelet-Derived Growth Factors.Journal of functional biomaterials · 2025Review
- Single-cell analysis reveals a unique microenvironment in peri-implantitis.Journal of clinical periodontology · 2024Article
- Peri-Implantitis.Dentistry journal · 2024Review
- A longitudinal analysis of the impact of nonsurgical and surgical treatment of peri-implantitis upon clinical parameters and implant stability quotient values. A 2-3-year follow-up.Clinical and experimental dental research · 2024Article
- Novel Flowchart Guiding the Non-Surgical and Surgical Management of Peri-Implant Complications: A Narrative Review.Bioengineering (Basel, Switzerland) · 2024Review
- Surgical regenerative methods for peri-implantitis treatment: A systematic review and meta-analysis.Journal of advanced periodontology & implant dentistry · 2024Article
- A conceptual review on reconstructive peri-implantitis therapy: Challenges and opportunities.Clinical and experimental dental research · 2023Review
- Bone tissue regeneration in peri-implantitis: A systematic review of randomized clinical trials.The Saudi dental journal · 2023Review
- Survival analysis of implants after surgical treatment of peri-implantitis based on bone loss severity and surgical technique: a retrospective study.BMC oral health · 2023Article
- Risk Factors for Complications Following Staged Alveolar Ridge Augmentation and Dental Implantation: A Retrospective Evaluation of 151 Cases with Allogeneic and 70 Cases with Autogenous Bone Blocks.Journal of clinical medicine · 2022Article
- Review
- Utilizing Previously Grafted Sinus as Intraoral Donor Site for Successful Augmentation in Peri-Implant Osseous Defect: A Case Report.Medicina (Kaunas, Lithuania) · 2022Article
- Comparative Transcriptome Analysis of Gingival Immune-Mediated Inflammation in Peri-Implantitis and Periodontitis Within the Same Host Environment.Journal of inflammation research · 2022Article
- Peri-Implantitis Regenerative Therapy: A Review.Biology · 2021Review
- Current Concepts on the Pathogenesis of Peri-implantitis: A Narrative Review.European journal of dentistry · 2021Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe purpose of the present study was to systematically review the literature on the surgical regenerative treatment of the peri-implantitis and to determine an effective therapeutic predictable option for their clinical management. MATERIAL AND
methodsThe study searched MEDLINE and EMBASE databases from 2006 to 2016. Clinical human studies that had reported changes in probing depth (PD) and/or bleeding on probing (BOP) and/or radiologic marginal bone level (RBL) changes after peri-implantitis surgical treatment at 12-month follow-up or longer were included accordingly to PRISMA guidelines.
resultsThe initial search obtained 883 citations. After screening and determination of eligibility, 18 articles were included in the review. The meta-analysis of selected studies revealed that the weighted mean RBL fill was 1.97 mm (95% confidence interval [CI] = 1.58 to 2.35 mm), PD reduction was 2.78 mm (95% CI = 2.31 to 3.25 mm), and BOP reduced by 52.5% (95% CI = 41.6 to 63.1%). Defect fill in studies using and not using barrier membranes for graft coverage was 1.86 mm (95% CI = 1.36 to 2.36 mm) and 2.12 mm (95% CI = 1.46 to 2.78 mm) correspondingly. High heterogeneity among the studies regarding defects morphology, surgical protocols, and selection of biomaterials were found.
conclusionsAll included studies underlined an improvement of clinical conditions after the surgical regenerative treatment of peri-implantitis, however, there is a lack of scientific evidence in the literature regarding the superiority of the regenerative versus non-regenerative surgical treatment. The presence of a barrier membrane or submergence in the regenerative procedure does not seem to be fundamental in order to obtain clinical success of the surgery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.