ArticleFrontiers in microbiology2016
Alteration of Fecal Microbiota Profiles in Juvenile Idiopathic Arthritis. Associations with HLA-B27 Allele and Disease Status.
Article in Frontiers in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05176795 (Study of the Determinants of Pediatric Onset Inflammatory Diseases), which is not on this map. Cited by 43 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Study of the Determinants of Pediatric Onset Inflammatory Diseases: Host-microbiota-environment Interactions
Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- Safety and efficacy of probiotic supplementation in 8 types of inflammatory arthritis: A systematic review and meta-analysis of 34 randomized controlled trials.Frontiers in immunology · 2022Pooled it
- Gut microbiota in children with juvenile idiopathic arthritis: characteristics, biomarker identification, and usefulness in clinical prediction.BMC genomics · 2020Trial
- The gut-joint axis in juvenile idiopathic arthritis.Arthritis research & therapy · 2026Review
- Composition of and changes in faecal microbiota in children diagnosed with oligoarticular juvenile idiopathic arthritis.Frontiers in medicine · 2026Article
- An etiopathogenesis of juvenile idiopathic arthritis: the protein-homeostasis-system hypothesis.Frontiers in pediatrics · 2026Review
- Oral health status and subgingival microbiota in children with juvenile idiopathic arthritis.Frontiers in cellular and infection microbiology · 2026Article
- The Intestinal Microbiome in Juvenile Idiopathic Arthritis-Results of a Single-Center Pilot Study from Poland.Journal of clinical medicine · 2025Article
- Intestinal Microbiota Contributes to the Development of Cardiovascular Inflammation and Vasculitis in Mice.Circulation research · 2025Article
- CODARFE: Unlocking the prediction of continuous environmental variables based on microbiome.GigaScience · 2025Article
- Age-stratification reveals age-specific intestinal microbiota signatures in juvenile idiopathic arthritis.Molecular and cellular pediatrics · 2024Article
- Article
- Causal effect of gut microbiota on juvenile idiopathic arthritis: A two-sample Mendelian a randomization study.Journal of cellular and molecular medicine · 2024Article
- Causal association of juvenile idiopathic arthritis or JIA-associated uveitis and gut microbiota: a bidirectional two-sample Mendelian randomisation study.Frontiers in immunology · 2024Article
- Causal association of gut microbiota on spondyloarthritis and its subtypes: a Mendelian randomization analysis.Frontiers in immunology · 2024Article
- Infant gut microbiota and environment associate with juvenile idiopathic arthritis many years prior to disease onset, especially in genetically vulnerable children.EBioMedicine · 2023Article
- Alterations in the cutaneous microbiome of patients with psoriasis and psoriatic arthritis reveal similarities between non-lesional and lesional skin.Annals of the rheumatic diseases · 2023Article
- Gut Microbiome - Should we treat the gut and not the bones?Journal of clinical orthopaedics and trauma · 2023Article
- Alterations in the gut virome in patients with ankylosing spondylitis.Frontiers in immunology · 2023Article
- Article
- A Pilot Study Investigating Faecal Microbiota After Two Dietary Interventions in Children with Juvenile Idiopathic Arthritis.Current microbiology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alteration of gut microbiota is involved in several chronic inflammatory and autoimmune diseases, including rheumatoid arthritis, and gut microbial "pro-arthritogenic" profiles have been hypothesized. Intestinal inflammation may be involved in spondyloarthropathies and in a subset of patients affected by Juvenile Idiopathic Arthritis (JIA), the most common chronic rheumatic disease of childhood. We compared the fecal microbiota composition of JIA patients with healthy subjects (HS), evaluating differences in microbial profiles between sub-categories of JIA, such as enthesitis-related arthritis (JIA-ERA), in which inflammation of entheses occurs, and polyarticular JIA, non-enthesitis related arthritis (JIA-nERA). Through taxon-level analysis, we discovered alteration of fecal microbiota components that could be involved in subclinical gut inflammation, and promotion of joint inflammation. We observed abundance in
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.