Evidence map›Paper›PMID 27833556›Full record

ArticleFrontiers in pharmacology2016

Increased Motor-Impairing Effects of the Neuroactive Steroid Pregnanolone in Mice with Targeted Inactivation of the GABA

Elli Leppä, Anni-Maija Linden, Maria I Aller, Peer Wulff, Olga Vekovischeva, Bernhard Luscher, Hartmut Lüddens, William Wisden, Esa R Korpi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Tonic GABAThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  3. An Emerging Circuit Pharmacology of GABATrends in pharmacological sciences · 2018
    Review
  4. γ2 GABAFrontiers in cellular neuroscience · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 5 countries.

Elli LeppäDepartment of Pharmacology, Faculty of Medicine, University of Helsinki Helsinki, Finland.
Anni-Maija LindenDepartment of Pharmacology, Faculty of Medicine, University of Helsinki Helsinki, Finland.
Maria I AllerInstituto de Neurociencias, Consejo Superior de Investigaciones Científicas, Universidad Miguel Hernández de Elche San Juan de Alicante, Spain.
Peer WulffInstitute of Physiology, University of Kiel Kiel, Germany.
Olga VekovischevaDepartment of Pharmacology, Faculty of Medicine, University of Helsinki Helsinki, Finland.
Bernhard LuscherDepartment of Biology, The Pennsylvania State University University Park, PA, USA.
Hartmut LüddensDepartment of Psychiatry and Psychotherapy, University Medical Center of the Johannes Gutenberg-University Mainz Mainz, Germany.
William WisdenDepartment of Life Sciences, Imperial College London London, UK.
Esa R KorpiDepartment of Pharmacology, Faculty of Medicine, University of Helsinki Helsinki, Finland.
University of Helsinki · FIConsejo Superior de Investigaciones Científicas · ESImperial College London · GBKiel University · DEPennsylvania State University · USUniversity Medical Center of the Johannes Gutenberg University Mainz · DE

Funding

GABAergic Control of Depression Related Brain StatesR01MH099851 · NIMH · PENNSYLVANIA STATE UNIVERSITY, THE · PI LUSCHER, BERNHARD · 2013 to 2019
$3.2M
Use of a mouse model of anxious depression to assess the safety of pediatric antiRC1MH089111 · NIMH · PENNSYLVANIA STATE UNIVERSITY, THE · PI LUSCHER, BERNHARD · 2009 to 2010
$828k
Medical Research Council G0800399NIMH NIH HHS R01 MH099851NIMH NIH HHS RC1 MH089111
6 · The paper itself

Abstract

Endogenous neurosteroids and neuroactive steroids have potent and widespread actions on the brain via inhibitory GABA

Indexed as

cerebellumextrasynaptic GABAA receptorsmotor performanceneurosteroidsPurkinje cells

Identifiers

PMID27833556
PMCPMC5081378
OpenAlexW2543127821

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.