ReviewWorld journal of gastroenterology2016
Indications and surgical options for small bowel, large bowel and perianal Crohn's disease.
Review in World journal of gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Preoperative Nutritional Conditioning of Crohn's Patients-Systematic Review of Current Evidence and Practice.Nutrients · 2017Pooled it
- Timing of first abdominal operation in Crohn's disease based on a diagnostic model.Scientific reports · 2024Trial
- Article
- Scrotal abscesses in perianal Crohn's disease: a retrospective cohort study of clinical presentation, management, and outcomes.Techniques in coloproctology · 2026Article
- A web-based prediction model using routinely available clinical variables to estimate surgical risk in Crohn's disease during remission or mild activity.Scientific reports · 2026Article
- [Interpretable machine learning-based predictive model for assessing abdominal surgery risk and biologic therapy efficacy in CDAI 0 to 1 level Crohn disease patients].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Article
- SAR Consensus Recommendations for Defining Small Bowel Crohn Disease Strictures at CT and MR Enterography.Radiology · 2025Review
- Insufficiency of ileocolic anastomosis in Crohn's disease patients - prevention and treatment.World journal of gastrointestinal surgery · 2025Article
- Optimizing Biologic Therapy for the Prevention of Post-Operative Recurrence in Crohn's Disease: Current Evidence and Future Perspectives.Biomedicines · 2025Review
- Surgical and non-surgical risk factors affecting the insufficiency of ileocolic anastomosis after first-time surgery in Crohn's disease patients.World journal of gastrointestinal surgery · 2024Article
- Long-Term Outcome of Surgery for Perianal Crohn's Fistula.Medicina (Kaunas, Lithuania) · 2024Article
- Clinical outcomes and perioperative morbidity and mortality following segmental resections of the colon for Crohn's colitis.International journal of colorectal disease · 2024Article
- A comprehensive review and update on acute severe lower gastrointestinal bleeding in Crohn's disease: a management algorithm.Gastroenterology report · 2024Review
- Stricture dilationTherapeutic advances in gastroenterology · 2024Article
- Factors associated with surgical resection in patients with Crohn's disease: long-term evaluation.Acta cirurgica brasileira · 2024Article
- Predicting Risk of Surgery in Patients With Small Bowel Crohn's Disease Strictures Using Computed Tomography and Magnetic Resonance Enterography.Inflammatory bowel diseases · 2022Article
- Factors associated with stoma formation in ileocolic resection for Crohn's disease and the development of a predictive scoring system.Langenbeck's archives of surgery · 2022Article
- The effects of ustekinumab on small intestinal lesions and stenotic lesions.Nagoya journal of medical science · 2022Article
- Therapeutic strategies in Crohn's disease in an emergency surgical setting.World journal of gastroenterology · 2022Review
- Laparoscopy for Crohn's disease: A comprehensive exploration of minimally invasive surgical techniques.World journal of gastrointestinal surgery · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite advancements in medical therapy of Crohn's disease (CD), majority of patients with CD will eventually require surgical intervention, with at least a third of patients requiring multiple surgeries. It is important to understand the role and timing of surgery, with the goals of therapy to reduce the need for surgery without increasing the odds of emergency surgery and its associated morbidity, as well as to limit surgical recurrence and avoid intestinal failure. The profile of CD patients requiring surgical intervention has changed over the decades with improvements in medical therapy with immunomodulators and biological agents. The most common indication for surgery is obstruction from stricturing disease, followed by abscesses and fistulae. The risk of gastrointestinal bleeding in CD is high but the likelihood of needing surgery for bleeding is low. Most major gastrointestinal bleeding episodes resolve spontaneously, albeit the risk of re-bleeding is high. The risk of colorectal cancer associated with CD is low. While current surgical guidelines recommend a total proctocolectomy for colorectal cancer associated with CD, subtotal colectomy or segmental colectomy with endoscopic surveillance may be a reasonable option. Approximately 20%-40% of CD patients will need perianal surgery during their lifetime. This review assesses the practice parameters and guidelines in the surgical management of CD, with a focus on the indications for surgery in CD (and when not to operate), and a critical evaluation of the timing and surgical options available to improve outcomes and reduce recurrence rates.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.