ArticleThe Journal of experimental medicine1989
Human eosinophils express CD4 protein and bind human immunodeficiency virus 1 gp120.
Article in The Journal of experimental medicine, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 134 citations in OpenAlex.
- Considering treatment of male genital schistosomiasis as a tool for future HIV prevention: a systematic review.International journal of public health · 2015Pooled it
- Article
- Chimeric antigen receptor T cells march into T cell malignancies.Journal of cancer research and clinical oncology · 2023Review
- Immunity and Breast Cancer: Focus on Eosinophils.Biomedicines · 2021Review
- Kinetic studies of galectin-10 release from eosinophils exposed to proliferating T cells.Clinical and experimental immunology · 2021Article
- Facts and Challenges in Immunotherapy for T-Cell Acute Lymphoblastic Leukemia.International journal of molecular sciences · 2020Review
- Eosinophils from Physiology to Disease: A Comprehensive Review.BioMed research international · 2018Review
- HIV infection: focus on the innate immune cells.Immunologic research · 2016Review
- Until Death Do Us Part: Necrosis and Oxidation Promote the Tumor Microenvironment.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2016Review
- Cell separation: Terminology and practical considerations.Journal of tissue engineering · 2013Article
- The influence of different helminth infection phenotypes on immune responses against HIV in co-infected adults in South Africa.BMC infectious diseases · 2011Article
- Stem cell-based approaches to treating HIV infection.Current opinion in HIV and AIDS · 2011Review
- A functional gammadeltaTCR/CD3 complex distinct from gammadeltaT cells is expressed by human eosinophils.PloS one · 2009Article
- The CD4 molecule on CD8+ T lymphocytes directly enhances the immune response to viral and cellular antigens.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Interleukin-16 expression and release in bullous pemphigoid.Clinical and experimental immunology · 2004Article
- Eosinophilia in patients infected with the human immunodeficiency virus.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 1997Article
- Type 1 and type 2 cytokine dysregulation in human infectious, neoplastic, and inflammatory diseases.Clinical microbiology reviews · 1996Review
- Analysis of recombinant human tumour necrosis factor-alpha-induced CD4 expression on human eosinophils.Immunology · 1996Article
- LW/SO cell line: a tool for studying the phenotypical characterization and commitment of hematopoietic stem cells.Annals of hematology · 1996Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The CD4 glycoprotein, expressed on leukocytes belonging to subsets of T lymphocytes and to cells of monocyte/macrophage lineage, participates in the functioning of T cells and serves as a receptor for HIV-1 and HIV-2. Human eosinophils, a class of granulocytic leukocytes, have been found to express CD4. With anti-CD4 mAbs CD4 was demonstrable on eosinophils from both normal and eosinophilic donors. Eosinophils synthesized a 55-kD CD4 polypeptide immunoprecipitable with two anti-CD4 mAbs. Eosinophil CD4 bound HIV-1 gp120 as assessed by competition for anti-OKT4A, but not anti-OKT4, mAb binding. Eosinophils, normally rich in gastrointestinal and genitourinary tract tissues, increase in numbers in patients with metazoan parasitic infections. In these sites and diseases, CD4 expression by eosinophils may be pertinent to their immunologic functions and could make these cells susceptible to HIV infection.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.