Evidence map›Paper›PMID 27833137›Full record

ArticleScientific reports2016

Inflammatory cytokine IL6 cooperates with CUDR to aggravate hepatocyte-like stem cells malignant transformation through NF-κB signaling.

Qidi Zheng, Zhuojia Lin, Xiaonan Li, Xiaoru Xin, Mengying Wu, Jiahui An, Xin Gui, Tianming Li, Hu Pu, Haiyan Li and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. The mMolecular cancer · 2021
    Review
  7. Article
  8. Advances in research on the interaction between inflammation and cancer.The Journal of international medical research · 2020
    Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. The emerging role of lncRNAs in the regulation of cancer stem cells.Cellular oncology (Dordrecht, Netherlands) · 2018
    Review
  14. Article
  15. Emerging roles of long non-coding RNAs in tumor metabolism.Journal of hematology & oncology · 2018
    Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Qidi ZhengSchool of Life Science and Technology, Tongji University, Shanghai, 200092, China.
Zhuojia LinSchool of Life Science and Technology, Tongji University, Shanghai, 200092, China.
Xiaonan LiSchool of Life Science and Technology, Tongji University, Shanghai, 200092, China.
Xiaoru XinSchool of Life Science and Technology, Tongji University, Shanghai, 200092, China.
Mengying WuSchool of Life Science and Technology, Tongji University, Shanghai, 200092, China.
Jiahui AnSchool of Life Science and Technology, Tongji University, Shanghai, 200092, China.
Xin GuiSchool of Life Science and Technology, Tongji University, Shanghai, 200092, China.
Tianming LiSchool of Life Science and Technology, Tongji University, Shanghai, 200092, China.
Hu PuSchool of Life Science and Technology, Tongji University, Shanghai, 200092, China.
Haiyan LiSchool of Life Science and Technology, Tongji University, Shanghai, 200092, China.
Dongdong LuSchool of Life Science and Technology, Tongji University, Shanghai, 200092, China.
Tongji University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammatory cytokines and lncRNAs are closely associated with tumorigenesis. Herein, we reveal inflammatory cytokines IL6 cooperates with long noncoding RNA CUDR to trigger the malignant transformation of human embryonic stem cells-derived hepatocyte-like stem cells. Mechanistically, IL6 cooperates with CUDR to cause MELLT3 to interact with SUV39h1 mRNA3'UTR and promote SUV39h1 expression. Moreover, the excessive SUV39h1 also increases tri-methylation of histone H3 on nineth lysine (H3K9me3). Intriguingly, under inflammatory conditions, H3K9me3 promotes the excessive expression and phosphorylation of NF-κB, and in turn, phorsphorylated NF-κB promotes the expression and phosphorylation of Stat3. Furthermore, that the phosphorylated Stat3 loads onto the promoter region of miRs and lncRNAs. Ultimately, the abnormal expression of miRs and lncRNAs increased telomerase activity, telomere length and microsatellite instability (MSI), leading to malignant transformation of hepatocyte-like stem cells.

Indexed as

Cell Transformation, NeoplasticAnimalsCell LineGene Expression Regulation, NeoplasticHepatocytesHistone-Lysine N-MethyltransferaseHumansInterleukin-6LiverLiver Neoplasms, ExperimentalMethyltransferasesMice, Inbred BALB CMicroRNAsMicrosatellite InstabilityNF-kappa BPhosphorylationHistone-Lysine N-MethyltransferaseIL6 protein, humanInterleukin-6MethyltransferasesMicroRNAsNF-kappa BRepressor ProteinsRNA, Long NoncodingSTAT3 protein, humanSTAT3 Transcription FactorSUV39H1 protein, humanSUV39H2 protein, humanTelomeraseUCA1 RNA, human

Identifiers

PMID27833137
PMCPMC5104983
OpenAlexW2552069699

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.