SynthesisOncotarget2016
Prognostic significance of pretreatment elevated platelet count in patients with colorectal cancer: a meta-analysis.
Synthesis in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.
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Who cites it
42 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Factors affecting survival in patients with colorectal cancer: an umbrella review.Journal of translational medicine · 2025Pooled it
- Revisiting the association between pretreatment thrombocytosis and cancer survival outcomes: an umbrella review of meta-analyses.BMC cancer · 2024Pooled it
- Prognostic role of pretreatment thrombocytosis on survival in patients with cervical cancer: a systematic review and meta-analysis.World journal of surgical oncology · 2019Pooled it
- Interpretable AI-driven prediction of early postoperative recurrence in locally advanced rectal cancer using the Systemic Inflammatory-Nutritional Index (SINTI): A multi-center study and clinical web tool.International journal of colorectal disease · 2026Article
- Microenvironment, systemic inflammatory response and tumor markers considering consensus molecular subtypes of colorectal cancer.Pathology oncology research : POR · 2024Article
- The usefulness of red blood cell distribution width and its ratio with platelet count in breast cancer after surgery and adjuvant treatment: a retrospective study.Gland surgery · 2022Article
- Associations of Complete Blood Count Parameters with Disease-Free Survival in Right- and Left-Sided Colorectal Cancer Patients.Journal of personalized medicine · 2022Article
- Platelet detection as a new liquid biopsy tool for human cancers.Frontiers in oncology · 2022Review
- Prognostic significance of the combination of preoperative red cell distribution width and platelet distribution width in patients with gastric cancer.BMC cancer · 2021Article
- Prognostic value of inflammation-based indices in patients with resected hepatocellular carcinoma.BMC cancer · 2021Article
- Decreased mean platelet volume predicts poor prognosis in patients with pancreatic cancer.BMC surgery · 2021Article
- Serum and Whole Blood Cu and Zn Status in Predicting Mortality in Lung Cancer Patients.Nutrients · 2020Article
- Mean platelet volume and platelet distribution width serve as prognostic biomarkers in skull base chordoma: a retrospective study.BMC cancer · 2020Article
- The predictive value of inflammatory markers for pathological response of ipsilateral supraclavicular lymph nodes and for prognosis in breast cancer after neoadjuvant chemotherapy.Gland surgery · 2020Article
- Reduced mean platelet volume levels predict shorter survival in patients with resectable pancreatic ductal adenocarcinoma and type 2 diabetes.BMC gastroenterology · 2020Article
- Elevated platelet distribution width predicts poor prognosis in hilar cholangiocarcinoma.Medicine · 2020Observational
- The postoperative platelet distribution width is useful for predicting the prognosis in patients with esophageal squamous cell carcinoma.Surgery today · 2020Article
- Prognostic significance of platelet × C-reactive protein multiplier in patients with esophageal squamous cell carcinoma.Surgery today · 2020Article
- Higher platelet distribution width is associated with unfavorable prognosis in ovarian cancer.Cancer biomarkers : section A of Disease markers · 2020Article
- Neutrophil-to-mean platelet volume ratio as a new predictor for overall and cancer-specific survival in patients with localized clear cell renal cell carcinoma.Archives of medical science : AMS · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe prognostic effect of pretreatment elevated platelet count remains controversial in colorectal cancer patients. We conducted this meta-analysis to evaluate the prognostic impact of it in these patients.
methodsPubMed, EMBASE and Cochrane Library were searched and studies on the prognostic significance of pretreatment elevated platelet count in colorectal patients were identified. We performed the meta-analysis, using overall survival and disease-free survival as outcomes and presenting data with hazard ratio and its 95% confidence interval. Heterogeneity among studies and publication bias were also evaluated.
resultsThirty studies were included in the meta-analysis. Compared with normal platelet count, pretreatment elevated platelet count was associated with poorer overall survival (Hazard ratio = 1.837, 95% confidence interval, 1.497 to 2.255, p = 0.000) and poorer disease-free survival (Hazard ratio = 1.635, 95% confidence interval, 1.237 to 2.160, p = 0.001) in patients with colorectal cancer. In subgroup analyses, pretreatment elevated platelet count was also associated with poorer overall survival and disease-free survival in most subgroups.
conclusionPretreatment elevated platelet count was an independent prognostic factor of overall survival and disease-free survival in colorectal cancer patients. Large-scale prospective studies and a validation study are warranted.
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