Evidence map›Paper›PMID 27833083›Full record

ArticleOncotarget2016

Knockdown of long non-coding RNA CCAT2 suppressed proliferation and migration of glioma cells.

Hua Guo, Guowen Hu, Qing Yang, Pei Zhang, Wei Kuang, Xingen Zhu, Lei Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  16. Extracellular Vesicles Are Key Regulators of Tumor Neovasculature.Frontiers in cell and developmental biology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hua GuoDepartment of Neurosurgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, China.
Guowen HuDepartment of Neurosurgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, China.
Qing YangDepartment of Respiratory Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, China.
Pei ZhangDepartment of Neurosurgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, China.
Wei KuangDepartment of Neurosurgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, China.
Xingen ZhuDepartment of Neurosurgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, China.
Lei WuDepartment of Neurosurgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long non-coding RNA colon cancer-associated transcript 2 (CCAT2) is commonly investigated in a number of cancers. However, little is known of its expression and biological function in glioma biology. In the current study, we used quantitative real-time PCR (qRT-PCR) to determine the expression of CCAT2 in glioma tissues. We found that expression of CCAT2 was up-regulated in glioma tissues and significantly correlated with the advanced tumor stage (III/IV). Functional assays in vitro and in vivo demonstrated that knockdown of CCAT2 could inhibit proliferation, cell cycle progression and migration of glioma cells. Further analysis indicated the effect of CCAT2 knockdown on glioma cell phenotype through inhibiting Wnt/β-catenin signal pathway activity. Thus, our study provides evidence that CCAT2 may function as a potential biomarker for glioma.

Indexed as

Cell MovementCell ProliferationGene Knockdown TechniquesAdolescentAdultAgedAged, 80 and overAnimalsBiomarkers, TumorBrain NeoplasmsCell CycleCell Line, TumorChildDown-RegulationFemaleGene Expression Regulation, NeoplasticBiomarkers, Tumorlong non-coding RNA CCAT2, humanRNA, Long NoncodingCCK-8, cell counting kit-8lncRNA, long non-coding RNA (lncRNAs)qRT-PCR, quantitative real-time PCR

Identifiers

PMID27833083
PMCPMC5348431

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.