Article in Behavioural brain research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
2 citing papers in PubMed, 3 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
6 authors at 4 institutions in 1 country.
Tunde AkinyekeDepartment of Behavioral Neuroscience, ONPRC, Oregon Health and Science University, Portland, OR 97239, United States.
Sydney J WeberDepartment of Behavioral Neuroscience, ONPRC, Oregon Health and Science University, Portland, OR 97239, United States.
April T DavenportDepartment of Physiology and Pharmacology, Wake Forest School of Medicine, Winston Salem, NC 27106, United States.
Erich J BakerSchool of Engineering and Department of Computer Science, Baylor University Waco, TX 76978, United States.
James B DaunaisDepartment of Physiology and Pharmacology, Wake Forest School of Medicine, Winston Salem, NC 27106, United States.
Jacob RaberDepartment of Behavioral Neuroscience, ONPRC, Oregon Health and Science University, Portland, OR 97239, United States; Departments of Neurology and Radiation Medicine, Division of Neuroscience, ONPRC, Oregon Health and Science University, Portland, OR 97239, United States. Electronic address: raberj@ohsu.edu.
Oregon Health & Science University · USWake Forest University · USBaylor University · USOregon National Primate Research Center · US
Funding
MODE OF ACTION OF ENVIRONMENTAL TOXICANTST32ES007060 · NIEHS · OREGON STATE UNIVERSITY · PI Jamie DeWitt, Siva Kumar Kolluri · 1985 to 2026
$11.6M
BIOLOGICAL BASES OF ALCOHOLISMT32AA007468 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Andrey E Ryabinin · 1987 to 2026
$11.3M
Monkey Alcohol Tissue Research Resource (MATRR)R24AA019431 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Mary Lauren Benton, Verginia Carmella Cuzon Carlson · 2010 to 2026
$10.3M
Early Stress & Alcoholism: Neurobiological AnalysisU01AA014106 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI FRIEDMAN, DAVID P · 2003 to 2011
$3.4M
POST-DOCTORAL TRAINING PROGRAM IN ALCOHOL STUDIEST32AA007290 · NIAAA · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI SHEILA MARIE ALESSI · 1985 to 2026
$3.2M
Mouse Genetic Models for Alcohol ResearchR24AA020245 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI PHILLIPS, TAMARA J. · 2011 to 2020
$2.3M
Epigenetics underlies long-term risk of relapse during abstinenceR01AA021468 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI GUIZZETTI, MARINA · 2013 to 2017
Alcoholism is a disorder categorized by significant impairment that is directly related to persistent and extreme use of alcohol. The effects of alcoholism on c-Myc protein expression in the brain have been scarcely studied. This is the first study to investigate the role different characteristics of alcoholism have on c-Myc protein in the brain. We analyzed c-Myc protein in the hypothalamus and amygdala from five different animal models of alcohol abuse. c-Myc protein was increased following acute ethanol exposure in a mouse knockout model and following chronic ethanol consumption in vervet monkeys. We also observed increases in c-Myc protein exposure in animals that are genetically predisposed to alcohol and methamphetamine abuse. Lastly, c-Myc protein was increased in animals that were acutely exposed to methamphetamine when compared to control treated animals. These results suggest that in substance abuse c-Myc plays an important role in the brain's response.
Indexed as
AlcoholismAnimalsBrainCentral Nervous System DepressantsCentral Nervous System StimulantsChlorocebus aethiopsCyclin-Dependent Kinase Inhibitor p21Disease Models, AnimalEthanolGene Expression RegulationGenetic Predisposition to DiseaseMethamphetamineMiceMice, KnockoutProto-Oncogene Proteins c-mycReceptors, Metabotropic GlutamateCentral Nervous System DepressantsCentral Nervous System StimulantsCyclin-Dependent Kinase Inhibitor p21Ethanolmetabotropic glutamate receptor 8MethamphetamineProto-Oncogene Proteins c-mycReceptors, Metabotropic GlutamateAlcoholismc-MycPhosphorylationPreferenceWithdrawal
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Effects of alcohol on c-Myc protein in the brain. · full record | OpenQuestion