Evidence map›Paper›PMID 27832939›Full record

ReviewJournal of molecular and cellular cardiology2016

Roles and regulation of protein phosphatase 2A (PP2A) in the heart.

Ellen R Lubbers, Peter J Mohler

Abstract readReview
In one paragraph

Review in Journal of molecular and cellular cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 80 citations in OpenAlex.

  1. Review
  2. Article
  3. 2-Aminoethoxydiphenyl borate induces arrhythmias via Cx43-S282 dephosphorylation.In vitro cellular & developmental biology. Animal · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Downregulation of protein phosphatase 2Aα in asthmatic airway smooth muscle.American journal of physiology. Lung cellular and molecular physiology · 2024
    Article
  12. Loss of protein phosphatase 2A regulatory subunitFrontiers in cardiovascular medicine · 2024
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ellen R LubbersDorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, United States; Department of Physiology & Cell Biology, The Ohio State University Wexner Medical Center, Columbus, OH, United States.
Peter J MohlerDorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, United States; Department of Physiology & Cell Biology, The Ohio State University Wexner Medical Center, Columbus, OH, United States; Department of Internal Medicine, Division of Cardiovascular Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, United States. Electronic address: peter.mohler@osumc.edu.
The Ohio State University Wexner Medical Center · US

Funding

Role of spectrin/ankyrin-G complex in myocyte signaling and cardiac excitabilityR01HL083422 · NHLBI · VANDERBILT UNIVERSITY · PI MOHLER, PETER J. · 2006 to 2016
$3.8M
Role of ankyrin-B in human arrhythmiaR01HL084583 · NHLBI · UNIVERSITY OF IOWA · PI MOHLER, PETER J. · 2006 to 2015
$3.4M
EHD proteins in cardiac membrane protein targeting and remodelingR01HL114383 · NHLBI · OHIO STATE UNIVERSITY · PI BOYDEN, PENELOPE ALTMAN, MOHLER, PETER J. · 2013 to 2016
$2.1M
Defining the Role of Alpha II Spectrin in Cardiac Function and DiseaseF30HL137331 · NHLBI · OHIO STATE UNIVERSITY · PI LUBBERS, ELLEN · 2017 to 2020
$176k
NHLBI NIH HHS F30 HL137331NHLBI NIH HHS R01 HL083422NHLBI NIH HHS R01 HL084583NHLBI NIH HHS R01 HL114383
6 · The paper itself

Abstract

Reversible protein phosphorylation is central to a variety of cardiac processes including excitation-contraction coupling, Ca

Indexed as

AnimalsGene Expression RegulationHeart DiseasesHoloenzymesHumansIsoenzymesMolecular Targeted TherapyMultigene FamilyMyocardial ContractionMyocardiumProtein BindingProtein Interaction Domains and MotifsProtein KinasesProtein Phosphatase 2Protein Processing, Post-TranslationalRNA InterferenceHoloenzymesIsoenzymesProtein KinasesProtein Phosphatase 2ArrhythmiaCardiac diseaseIon channelPP2AProtein phosphatases

Identifiers

PMID27832939
PMCPMC5939568
OpenAlexW2550469153

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.