Evidence map›Paper›PMID 27832931›Full record

ReviewSeminars in perinatology2017

Cytokines and growth factors in the developing intestine and during necrotizing enterocolitis.

Krishnan MohanKumar, Kopperuncholan Namachivayam, Thao T B Ho, Benjamin A Torres, Robin K Ohls, Akhil Maheshwari

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Seminars in perinatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 2 pooled it
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 71 citations in OpenAlex.

  1. Pooled it
  2. The impact of environmental pollution on the quality of mother's milk.Environmental science and pollution research international · 2019
    Pooled it
  3. Article
  4. Article
  5. [Risk factors for white matter damage in preterm infants with necrotizing enterocolitis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Blood absolute monocyte count trends in preterm infants with suspected necrotizing enterocolitis: an adjunct tool for diagnosis?Journal of perinatology : official journal of the California Perinatal Association · 2024
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Krishnan MohanKumarDepartment of Pediatrics, Morsani College of Medicine, Tampa, FL.
Kopperuncholan NamachivayamDepartment of Pediatrics, Morsani College of Medicine, Tampa, FL.
Thao T B HoDepartment of Pediatrics, Morsani College of Medicine, Tampa, FL.
Benjamin A TorresDepartment of Pediatrics, Morsani College of Medicine, Tampa, FL.
Robin K OhlsDepartment of Pediatrics, University of New Mexico, Albuquerque, NM.
Akhil MaheshwariDepartment of Pediatrics, Morsani College of Medicine, Tampa, FL; Departments of Molecular Medicine, Morsani College of Medicine, Tampa, FL; Department of Community and Family Health, College of Public Health, University of South Florida, 1 Tampa General Circle, Suite F170, Tampa, FL. Electronic address: akhilm@health.usf.edu.
University of New Mexico · USUniversity of South Florida · US

Funding

Role of Transforming Growth Factor-beta in Neonatal Necrotizing EnterocolitisR01HD059142 · NICHD · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MAHESHWARI, AKHIL · 2009 to 2013
$1.7M
Red Cell Transfusion-associated Necrotizing Enterocolitis in Premature InfantsR01HL124078 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI KRISHNAN, MOHAN KUMAR · 2015 to 2018
$1.5M
NHLBI NIH HHS R01 HL124078NICHD NIH HHS R01 HD059142
6 · The paper itself

Abstract

Cytokines and growth factors play diverse roles in the uninflamed fetal/neonatal intestinal mucosa and in the development of inflammatory bowel injury during necrotizing enterocolitis (NEC). During gestational development and the early neonatal period, the fetal/premature intestine is exposed to high levels of many "inflammatory" cytokines and growth factors, first via swallowed amniotic fluid in utero and then, after birth, in colostrum and mother's milk. This article reviews the dual, seemingly counter-intuitive roles of cytokines, where these agents play a "trophic" role and promote maturation of the uninflamed mucosa, but can also cause inflammation and promote intestinal injury during NEC.

Indexed as

CytokinesDisease SusceptibilityEnterocolitis, NecrotizingGene Expression Regulation, DevelopmentalHeparin-binding EGF-like Growth FactorHumansImmunity, InnateInfant, Extremely Low Birth WeightInfant, Extremely PrematureInfant, NewbornInfant Nutritional Physiological PhenomenaInfant, Premature, DiseasesInflammationIntestinal MucosaCytokinesHeparin-binding EGF-like Growth FactorCytokinesGrowth factorsIntestinal injuryNECPrevention

Identifiers

PMID27832931
PMCPMC5334139
OpenAlexW2556966997

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.