Trial reportJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2016
Antecedent hypertension and myocardial injury in patients with reperfused ST-elevation myocardial infarction.
Trial report in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00712101 (Prospective Randomized Controlled Clinical Study to Compare Abciximab-bolus i.v. Versus i.c. in Primary PCI in Patients With Acute ST-elevation Myocardial Infarction), which is not on this map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prospective Randomized Controlled Clinical Study to Compare Abciximab-bolus i.v. Versus i.c. in Primary PCI in Patients With Acute ST-elevation Myocardial Infarction
Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Determinants and prognostic relevance of aortic stiffness in patients with recent ST-elevation myocardial infarction.The international journal of cardiovascular imaging · 2022Trial
- Emerging Prognostic Risk Factors in Acute Coronary Syndromes: Beyond Traditional Risk Assessment.Journal of clinical medicine · 2026Review
- Smoking cessation after first STEMI enhances infarct healing: a cardiac MRI study.European heart journal. Cardiovascular Imaging · 2026Article
- Article
- Review
- Association between homocysteine and blood pressure in the NHANES 2003-2006: the mediating role of Vitamin C.Frontiers in nutrition · 2024Article
- Coronary No-Reflow after Primary Percutaneous Coronary Intervention-Current Knowledge on Pathophysiology, Diagnosis, Clinical Impact and Therapy.Journal of clinical medicine · 2023Review
- A nomogramic model for predicting the left ventricular ejection fraction of STEMI patients after thrombolysis-transfer PCI.Frontiers in cardiovascular medicine · 2023Article
- Prediction models for major adverse cardiovascular events following ST-segment elevation myocardial infarction and subgroup-specific performance.Frontiers in cardiovascular medicine · 2023Article
- Risk factors, prediction model, and prognosis analysis of myocardial injury after acute upper gastrointestinal bleeding.Frontiers in cardiovascular medicine · 2022Article
- Review
- Predictors of Microvascular Reperfusion After Myocardial Infarction.Current cardiology reports · 2021Review
- Global longitudinal strain by feature tracking for optimized prediction of adverse remodeling after ST-elevation myocardial infarction.Clinical research in cardiology : official journal of the German Cardiac Society · 2021Observational
- Pathophysiology and diagnosis of coronary microvascular dysfunction in ST-elevation myocardial infarction.Cardiovascular research · 2020Review
- Review
- Journal of Cardiovascular Magnetic Resonance 2017.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2018Review
- Hypertension, Microvascular Pathology, and Prognosis After an Acute Myocardial Infarction.Hypertension (Dallas, Tex. : 1979) · 2018Observational
- Review of Journal of Cardiovascular Magnetic Resonance (JCMR) 2015-2016 and transition of the JCMR office to Boston.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAntecedent hypertension is associated with poor outcome in patients with ST-elevation myocardial infarction (STEMI). Whether differences in myocardial salvage, infarct size and microvascular injury contribute to the adverse outcome is unknown. We investigated the association between antecedent hypertension and cardiovascular magnetic resonance (CMR) parameters of myocardial salvage and damage in a multicenter CMR substudy of the AIDA-STEMI trial (Abciximab Intracoronary versus intravenously Drug Application in ST-elevation myocardial infarction).
methodsWe analyzed 792 consecutive STEMI patients reperfused within 12 h after symptom onset. Patients underwent CMR imaging for assessment of myocardial salvage, infarct size and microvascular obstruction within 10 days after infarction. Major adverse cardiac events (MACE) were recorded at 12-month follow-up.
resultsAntecedent hypertension was present in 540 patients (68 %) and was associated with a significantly increased baseline risk profile (advanced age, higher body mass index, higher incidence of diabetes, hypercholesterolemia, previous angioplasty and multivessel disease, p < 0.001 for all). MACE were more frequent in patients with hypertension as compared to patients without hypertension (45 [8 %] vs. 8 [3 %], p < 0.01). Antecedent hypertension remained an independent predictor of MACE after multivariate adjustment (hazard ratio 3.42 [confidence interval 1.45-8.08], p < 0.01). There was, however, no significant difference in the area at risk, infarct size, myocardial salvage index, extent of microvascular obstruction, and left ventricular ejection fraction between the groups (all p > 0.05).
conclusionDespite a higher rate of MACE in contemporary reperfused STEMI patients with antecedent hypertension, there was no difference in reperfusion efficacy, infarct size and reperfusion injury as visualized by CMR.
trial registrationNCT00712101 .
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.