Observational studyRespiratory research2016
Spirometric variability in smokers: transitions in COPD diagnosis in a five-year longitudinal study.
Observational study in Respiratory research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 48 citations in OpenAlex.
- Significant Spirometric Transitions and Preserved Ratio Impaired Spirometry Among Ever Smokers.Chest · 2022Trial
- Low appendicular muscle mass and the risk of COPD development in people with PRISm.ERJ open research · 2026Article
- Differences in systemic inflammation and prethrombotic biomarkers between AECOPD patients with and without pulmonary hypertension.Journal of inflammation (London, England) · 2026Article
- Precision treatment of COPD based on novel imaging phenotypes: a treatable traits approach.Respiratory research · 2026Review
- An Overview and Recent Developments in the Analysis of Multistate Processes.Statistics in medicine · 2026Review
- Physiological characteristics and temporal transitions of preserved ratio impaired spirometry.ERJ open research · 2026Article
- Preserved Ratio Impaired Spirometry (PRISm) from an Epidemiological Perspective.Journal of clinical medicine · 2025Article
- Spirometric pattern transitions in a World Trade Center occupational cohort on longitudinal surveillance.Respiratory medicine · 2025Article
- Nomogram to predict progression from preserved ratio impaired spirometry to chronic obstructive pulmonary disease.Scientific reports · 2025Article
- Risk of All-Cause Mortality in US Adults With Preserved Ratio Impaired Spirometry: An Observational Study.International journal of chronic obstructive pulmonary disease · 2025Observational
- The association between preserved ratio impaired spirometry (PRISm) and cognitive function among American older adults: the mediating role of systolic blood pressure.BMC geriatrics · 2024Article
- Pulmonary Function Tests: Easy Interpretation in Three Steps.Journal of clinical medicine · 2024Review
- Acute Exacerbation and Longitudinal Lung Function Change of Preserved Ratio Impaired Spirometry.International journal of chronic obstructive pulmonary disease · 2024Article
- From pre-COPD to COPD: a Simple, Low cost and easy to IMplement (SLIM) risk calculator.The European respiratory journal · 2023Article
- Associations Between Muscle Weakness and Clinical Outcomes in Current and Former Smokers.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2023Article
- The Clinical Spectrum of PRISm.American journal of respiratory and critical care medicine · 2022Article
- Restricted spirometry and cardiometabolic comorbidities: results from the international population based BOLD study.Respiratory research · 2022Article
- The Relationship Between BMI and Lung Function in Populations with Different Characteristics: A Cross-Sectional Study Based on the Enjoying Breathing Program in China.International journal of chronic obstructive pulmonary disease · 2022Article
- Asthma-COPD overlap in World Trade Center Health Registry enrollees, 2015-2016.The Journal of asthma : official journal of the Association for the Care of Asthma · 2021Article
- Preserved Ratio Impaired Spirometry in a Spirometry Database.Respiratory care · 2021Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundSpirometrically-defined chronic obstructive pulmonary disease (COPD) is considered progressive but its natural history is inadequately studied. We hypothesized that spirometrically-defined COPD states could undergo beneficial transitions.
methodsParticipants in the Lovelace Smokers' Cohort (n = 1553), primarily women, were longitudinally studied over 5 years. Spirometric states included normal postbronchodilator spirometry, COPD Stage I, Unclassified state, and COPD Stage II+, as defined by GOLD guidelines. Beneficial transitions included either a decrease in disease severity, including resolution of spirometric abnormality, or maintenance of non-diseased state. 'All smokers' (n = 1553) and subgroups with normal and abnormal spirometry at baseline (n = 956 and 597 respectively) were separately analyzed. Markov-like model of transition probabilities over an average follow-up period of 5 years were calculated.
resultsAmong 'all smokers', COPD Stage I, Unclassified, and COPD Stage II+ states were associated with probabilities of 16, 39, and 22 % respectively for beneficial transitions, and of 16, 35, and 4 % respectively for resolution. Beneficial transitions were more common for new-onset disease than for pre-existing disease (p < 0.001). Beneficial transitions were less common among older smokers, men, or those with bronchial hyperresponsiveness but more common among Hispanics and smokers with excess weight.
conclusionsThis observational study of ever smokers, shows that spirometrically-defined COPD states, may not be uniformly progressive and can improve or resolve over time. The implication of these findings is that the spirometric diagnosis of COPD can be unstable. Furthermore, COPD may have a pre-disease state when interventions might help reverse or change its natural history.
trial registrationNA.
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Registered trials
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