ArticleBMC microbiology2016
Lactobacillus acidophilus alleviates the inflammatory response to enterotoxigenic Escherichia coli K88 via inhibition of the NF-κB and p38 mitogen-activated protein kinase signaling pathways in piglets.
Article in BMC microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Pooled it
- Pooled it
- Serological Biomarkers and Diversion Colitis: Changes after Stimulation with Probiotics.Biomolecules · 2021Trial
- Tryptophan supplementation in low-protein diets of sows during late gestation and lactation: Effects on sow performance and piglet growth.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- The gut-liver axis in drug-induced liver injury (DILI): Interplay between gut microbiota, intestinal barrier, and immune system.Acta pharmaceutica Sinica. B · 2026Review
- Lacticaseibacillus paracasei KBL382 contributes to the immunomodulation in THP-1 cells.Journal of microbiology (Seoul, Korea) · 2026Article
- Inactivated Bacillus subtilis R0179 Inhibits Porphyromonas Gingivalis-Induced Gingival Inflammation Via TLR2/NF-κB Signaling in a Murine Model of Periodontitis.Inflammation · 2025Article
- Effects of probiotics, prebiotics, and synbiotics on the growth performance, biochemical indexes, and gut morphometry of turkeys.Frontiers in physiology · 2025Article
- Dietary Bacteriophage Administration Alleviates EnterotoxigenicInternational journal of molecular sciences · 2024Article
- Ningxiang Pig-DerivedAnimals : an open access journal from MDPI · 2024Article
- Microbial composition, functionality, and stress resilience or susceptibility: unraveling sex-specific patterns.Biology of sex differences · 2024Article
- Article
- MixedFrontiers in microbiology · 2024Article
- Supplementation of microencapsulated probiotics modulates gut health and intestinal microbiota.Food science & nutrition · 2023Article
- Microbiome in urological diseases: Axis crosstalk and bladder disorders.Investigative and clinical urology · 2023Review
- Interaction between gut microbiota and sex hormones and their relation to sexual dimorphism in metabolic diseases.Biology of sex differences · 2023Review
- Resilience or susceptibility to traumatic stress: Potential influence of the microbiome.Neurobiology of stress · 2022Article
- Effects of probiotics on Zebrafish model infected with Aeromonas hydrophila: spatial distribution, antimicrobial, and histopathological investigation.BMC microbiology · 2022Article
- Microencapsulated probiotic Lactiplantibacillus plantarum and/or Pediococcus acidilactici strains ameliorate diarrhoea in piglets challenged with enterotoxigenic Escherichia coli.Scientific reports · 2022Article
- Effect of Immune Stress on Growth Performance and Immune Functions of Livestock: Mechanisms and Prevention.Animals : an open access journal from MDPI · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA newly isolated L. acidophilus strain has been reported to have potential anti-inflammatory activities against lipopolysaccharide (LPS) challenge in piglet, while the details of the related inflammatory responses are limited. Here we aimed to analysis the ability of L. acidophilus to regulate inflammatory responses and to elucidate the mechanisms involved in its anti-inflammatory activity.
resultsThe ETEC (enterotoxigenic Escherichia coli) K88-induced up-regulations of IL-1β, IL-8 and TNF-α were obviously inhibited by L. acidophilus while IL-10 was significantly increased. Moreover, L. acidophilus down-regulated pattern recognition receptors TLR (Toll-like receptor) 2 and TLR4 expression in both spleen and mesenteric lymph nodes of ETEC-challenged piglets, in accompanied with the reduced phosphorylation levels of nuclear factor kappa B (NF-κB) p65 and mitogen-activated protein kinase (MAPK) p38 as well in spleen of ETEC-infected piglets. Furthermore, L.acidophilus significantly increased the expression of the negative regulators of TLRs signaling, including Tollip, IRAK-M, A20 and Bcl-3 in spleen of ETEC-challenged piglets.
conclusionsOur findings suggested that L. acidophilus regulated inflammatory response to ETEC via impairing both NF-κB and MAPK signaling pathways in piglets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.