Evidence map›Paper›PMID 27832596›Full record

ArticleJournal of neurophysiology2017

Cocaine sensitization increases subthreshold activity in dopamine neurons from the ventral tegmental area.

Francisco Arencibia-Albite, Rafael Vázquez-Torres, Carlos A Jiménez-Rivera

Open access · greenAbstract read
In one paragraph

Article in Journal of neurophysiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. IProgress in neuro-psychopharmacology & biological psychiatry · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Francisco Arencibia-AlbiteDepartment of Physiology, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico; and.
Rafael Vázquez-TorresDepartment of Physiology, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico; and.
Carlos A Jiménez-RiveraDepartment of Physiology, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico; and carlos.jimenez8@upr.edu.
University of Puerto Rico, Medical Sciences Campus · PR

Funding

TRANSLATIONAL PROTEOMICS CENTERG12MD007600 · NIMHD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI FERNANDEZ-REPOLLET, EMMA · 2012 to 2016
$11.0M
PKMzeta involvement in cocaine sensitizationSC1GM084854 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI JIMENEZ-RIVERA, CARLOS A · 2008 to 2016
$2.4M
NIGMS NIH HHS SC1 GM084854NIMHD NIH HHS G12 MD007600
6 · The paper itself

Abstract

The progressive escalation of psychomotor responses that results from repeated cocaine administration is termed sensitization. This phenomenon alters the intrinsic properties of dopamine (DA) neurons from the ventral tegmental area (VTA), leading to enhanced dopaminergic transmission in the mesocorticolimbic network. The mechanisms underlying this augmented excitation are nonetheless poorly understood. DA neurons display the hyperpolarization-activated, nonselective cation current, dubbed I NEW & NOTEWORTHY: This work uses a new approach that directly extracts important biophysical parameters from alpha function-evoked synaptic potentials. Two of these parameters are the cell membrane capacitance (C

Indexed as

AnimalsBiophysicsCentral Nervous System SensitizationCocaineDopaminergic NeuronsDopamine Uptake InhibitorsElectric StimulationExcitatory Postsynaptic PotentialsIn Vitro TechniquesMaleMotor ActivityRatsRats, Sprague-DawleyTime FactorsTyrosine 3-MonooxygenaseVentral Tegmental AreaCocaineDopamine Uptake InhibitorsTyrosine 3-MonooxygenasecapacitancecocaineEPSPh-currenttemporal summation

Identifiers

PMID27832596
PMCPMC5288483
OpenAlexW2551869203

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.