Evidence map›Paper›PMID 27832591›Full record

ArticleCell host & microbe2016

A Herpesvirus Protein Selectively Inhibits Cellular mRNA Nuclear Export.

Danyang Gong, Yong Hoon Kim, Yuchen Xiao, Yushen Du, Yafang Xie, Kevin K Lee, Jun Feng, Nisar Farhat, Dawei Zhao, Sara Shu and 6 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell host & microbe, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 56 citations in OpenAlex.

  1. Viral interference of nucleocytoplasmic transport.The Journal of biological chemistry · 2025
    Review
  2. Article
  3. Article
  4. ThebioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Crystal structure of the tegument protein UL82 (pp71) from human cytomegalovirus.Protein science : a publication of the Protein Society · 2024
    Article
  11. Interferon-International journal of molecular sciences · 2024
    Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Virus Infection and mRNA Nuclear Export.International journal of molecular sciences · 2023
    Review
  17. Structure and Function of the Nuclear Pore Complex.Cold Spring Harbor perspectives in biology · 2022
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Danyang GongDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Yong Hoon KimDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Yuchen XiaoDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Yushen DuDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Yafang XieDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Kevin K LeeSchool of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Jun FengDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Nisar FarhatDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Dawei ZhaoDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Sara ShuDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Xinghong DaiDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Sumit K ChandaInfectious and Inflammatory Disease Center, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA.
Tariq M RanaDepartment of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.
Nevan J KroganDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.
Ren SunDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Ting-Ting WuDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: twu@mednet.ucla.edu.
University of California, Los Angeles · USSanford Burnham Prebys Medical Discovery Institute · USUniversity of California San Diego · USUniversity of California, San Francisco · US

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
Virology CoreP01CA177322 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SUN, REN · 2014 to 2018
$8.7M
Modeling HIV/AIDS Associated Neurological Disorders with Human Pluripotent CellsDP1DA039562 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RANA, TARIQ M · 2015 to 2020
$3.9M
Regulation of HIV infection by Methamphetamine and non-coding RNAsR01DA030199 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RANA, TARIQ M · 2010 to 2014
$2.6M
Develop a therapeutic vaccine approach by removing viral immune evasionR01DE023591 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SUN, REN · 2013 to 2017
$1.9M
NCI NIH HHS P01 CA177322NCI NIH HHS P30 CA016042NIDA NIH HHS DP1 DA039562NIDA NIH HHS R01 DA030199NIDCR NIH HHS R01 DE023591
6 · The paper itself

Abstract

Nuclear mRNA export is highly regulated to ensure accurate cellular gene expression. Viral inhibition of cellular mRNA export can enhance viral access to the cellular translation machinery and prevent anti-viral protein production but is generally thought to be nonselective. We report that ORF10 of Kaposi's sarcoma-associated herpesvirus (KSHV), a nuclear DNA virus, inhibits mRNA export in a transcript-selective manner to control cellular gene expression. Nuclear export inhibition by ORF10 requires an interaction with an RNA export factor, Rae1. Genome-wide analysis reveals a subset of cellular mRNAs whose nuclear export is blocked by ORF10 with the 3' UTRs of ORF10-targeted transcripts conferring sensitivity to export inhibition. The ORF10-Rae1 interaction is important for the virus to express viral genes and produce infectious virions. These results suggest that a nuclear DNA virus can selectively interfere with RNA export to restrict host gene expression for optimal replication.

Indexed as

Active Transport, Cell NucleusHost-Pathogen InteractionsVirus ReplicationAnimalsCell LineGene Expression RegulationHerpesvirus 8, HumanHumansModels, BiologicalNuclear Matrix-Associated ProteinsNucleocytoplasmic Transport ProteinsProtein BindingRNA, MessengerViral ProteinsNuclear Matrix-Associated ProteinsNucleocytoplasmic Transport ProteinsRAE1 protein, humanRNA, MessengerViral Proteins3′ UTRherpesvirusKSHVlate genemRNA nuclear exportNup98ORF10Rae1

Identifiers

PMID27832591
PMCPMC5130111
OpenAlexW2551415494

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.