Evidence map›Paper›PMID 27832583›Full record

ArticleCell host & microbe2016

Salmonella Gives MARCH(ing) Orders to MHC-II.

Patrick A McLaughlin, Adrianus W M van der Velden

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Cell host & microbe, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Patrick A McLaughlinDepartment of Molecular Genetics and Microbiology and Center for Infectious Diseases, 130 Life Sciences Building, Stony Brook University, Stony Brook, NY 11794-5120, USA.
Adrianus W M van der VeldenDepartment of Molecular Genetics and Microbiology and Center for Infectious Diseases, 130 Life Sciences Building, Stony Brook University, Stony Brook, NY 11794-5120, USA. Electronic address: a.vandervelden@stonybrook.edu.
Stony Brook University · US

Funding

Inhibition of T cells by SalmonellaR01AI101221 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI VAN DER VELDEN, ADRIANUS WILHELMUS MARIA · 2013 to 2017
$1.9M
Medical Research Council MR/K027077/1NIAID NIH HHS R01 AI101221
6 · The paper itself

Abstract

How bacterial pathogens evade adaptive immunity is not well understood. In this issue of Cell Host & Microbe, Bayer-Santos et al. (2016) show that the Salmonella effector protein SteD mediates MARCH8-dependent ubiquitination of class II MHC molecules, thereby inhibiting antigen presentation and limiting T cell responses.

Indexed as

SalmonellaAntigen PresentationHistocompatibility Antigens Class IIT-LymphocytesUbiquitinationHistocompatibility Antigens Class II

Identifiers

PMID27832583
OpenAlexW2552488589

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.