ArticleJournal of the Association for Research in Otolaryngology : JARO2017
Long-Lasting forward Suppression of Spontaneous Firing in Auditory Neurons: Implication to the Residual Inhibition of Tinnitus.
Article in Journal of the Association for Research in Otolaryngology : JARO, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Guideline
- The longer, the better? Investigating the effect of prolonged acoustic stimulation on brief acoustic tinnitus suppression.BMC neurology · 2026Trial
- Tailor-made notched music training-induced residual inhibition in subjective tinnitus: resting-state EEG spectral power ratio evidence.Frontiers in neuroscience · 2026Trial
- Multiparametric Classification of Pure-tone Responses Distinguishes Neurons in Inferior Colliculus Subdivisions.bioRxiv : the preprint server for biology · 2026Article
- An Insight into Role of Auditory Brainstem in Tinnitus: A Systematic Review of Diagnostic Assessments.Audiology research · 2025Review
- Can Residual Inhibition Predict the Success of Sound Enrichment Treatment for Tinnitus?Brain and behavior · 2024Article
- A Pilot Study to Evaluate a Residual Inhibition Technique in Hearing Aids for Suppression of Tinnitus.Seminars in hearing · 2024Review
- Long-Duration Sound-Induced Facilitation Changes Population Activity in the Inferior Colliculus.Frontiers in systems neuroscience · 2022Article
- Sense and Sensibility: A Review of the Behavioral Neuroscience of Tinnitus Sound Therapy and a New Typology.Current topics in behavioral neurosciences · 2021Review
- Article
- Amplitude Modulated Noise for Tinnitus Suppression in Tonal and Noise-Like Tinnitus.Audiology & neuro-otology · 2019Article
- Sound Change Integration Error: An Explanatory Model of Tinnitus.Frontiers in neuroscience · 2018Article
- Brain Waves Evaluation of Sound Therapy in Chronic Subjective Tinnitus Cases Using Wavelet Decomposition.Frontiers in integrative neuroscience · 2018Article
- Susceptibility to Residual Inhibition Is Associated With Hearing Loss and Tinnitus Chronicity.Trends in hearingArticle
- Tinnitus Treatment Using Noninvasive and Minimally Invasive Electric Stimulation: Experimental Design and Feasibility.Trends in hearingArticle
- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Tinnitus is the perception of a sound that has no external source. Sound stimuli can suppress spontaneous firing in auditory neurons long after stimulus offset. It is unknown how changes in sound stimulus parameters affect this forward suppression. Using in vivo extracellular recording in awake mice, we found that about 40 % of spontaneously active inferior colliculus (IC) neurons exhibited forward suppression of spontaneous activity after sound offset. The duration of this suppression increased with sound duration and lasted about 40 s following a 30-s stimulus offset. Pure tones presented at the neuron's characteristic frequency (CF) were more effective in triggering suppression compared to non-CF or wideband noise stimuli. In contrast, non-CF stimuli often induced forward facilitation. About one third of IC neurons exhibited shorter suppression durations with each subsequent sound presentation. These characteristics of forward suppression are similar to the psychoacoustic properties of residual inhibition of tinnitus: a phenomenon of brief (about 30 s) suppression of tinnitus observed in tinnitus patients after sound presentations. Because elevated spontaneous firing in central auditory neurons has been linked to tinnitus, forward suppression of this firing with sound might be an underlying mechanism of residual inhibition.
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