Evidence map›Paper›PMID 27832425›Full record

ReviewWiener medizinische Wochenschrift (1946)2018

Histopathologic pitfalls of Mohs micrographic surgery and a review of tumor histology.

Katlein França, Yasser Alqubaisy, Ashraf Hassanein, Keyvan Nouri, Torello Lotti

Abstract readReview
PubMed Publisher
In one paragraph

Review in Wiener medizinische Wochenschrift (1946), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. [Use of modern imaging in dermatosurgery].Dermatologie (Heidelberg, Germany) · 2025
    Review
  3. Review
  4. Review
  5. Article
  6. Distinguishing malignant from benign microscopic skin lesions using desorption electrospray ionization mass spectrometry imaging.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Katlein FrançaDepartment of Dermatology & Cutaneous Surgery, Department of Psychiatry & Behavioral Sciences, Institute for Bioethics & Health Policy, University of Miami Miller School of Medicine, Miami, FL, USA. k.franca@med.miami.edu.ORCID http://orcid.org/0000-0002-4286-7169
Yasser AlqubaisyDepartment of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
Ashraf HassaneinDermatopathology Department, Florida Dermatalogic Surgery & Aesthetics Institute, The Villages, FL, USA.
Keyvan NouriDepartment of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
Torello LottiCentro Studi per la Ricerca Multidisciplinare e Rigenerativa, Università Degli Studi "G. Marconi", Rome, Italy.
University of Miami · USAdvanced Dermatology · USMarconi University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mohs micrographic surgery is a specialized subset of staged surgical excisions with each subsequent stage being driven largely by the histologic findings of the previous stage. Therefore, it is imperative that histologic analysis is performed in an accurate manner. Frozen section and tissue flattening is a crucial step in Mohs surgery. Frozen sections introduce certain artifacts and these artifacts must be interpreted in the correct context. Basal and squamous cell carcinomas are the most common tumors encountered in Mohs micrographic surgery, and their histopathology is also associated with certain "pitfalls". Basal cell carcinoma should be distinguished from hair follicles, folliculocentric basaloid proliferations, poromas, nevus sebaceous, desmoplastic trichoepitheliomas, and spiradenomas, to name but a few histologic entities. Similarly, squamous cell carcinoma should be distinguished from hypertrophic actinic keratoses, pseudoepitheliomatous hyperplasia, sebaceous carcinoma, and microcystic adnexal carcinoma. In addition, there are numerous subtypes of basal cell and squamous carcinomas that the Mohs surgeon should be aware of due to differences in the biologic behavior of these tumors. This review presents a number of the common histologic pitfalls of Mohs micrographic surgery and a review of tumor histology.

Indexed as

Skin NeoplasmsBasal Cell CarcinomaCarcinoma, Squamous CellHumansMohs SurgeryBasal cell carcinomaHistopathologic pitfallsMohs micrographic surgerySquamous cell carcinomaTumor histology

Identifiers

PMID27832425
OpenAlexW2562150976

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.