ArticleCalcified tissue international2017
Diets High in Fat or Fructose Differentially Modulate Bone Health and Lipid Metabolism.
Article in Calcified tissue international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- A pilot longitudinal spectral CT study of fructose-related bone microstructure in rats: exploring technical advantages.Frontiers in physiology · 2026Article
- Effects of a high-fat diet on gut microbiota and possible implications for bone health in male Wistar rats.Lipids · 2025Article
- Metabolic syndrome and its effect on immune cells in apical periodontitis- a narrative review.Clinical oral investigations · 2025Review
- The Effects of Different Dietary Patterns on Bone Health.Nutrients · 2024Review
- Magnesium Picolinate Improves Bone Formation by Regulation of RANK/RANKL/OPG and BMP-2/Runx2 Signaling Pathways in High-Fat Fed Rats.Nutrients · 2021Article
- MicroRNA-29a in Osteoblasts Represses High-Fat Diet-Mediated Osteoporosis and Body Adiposis through Targeting Leptin.International journal of molecular sciences · 2021Article
- Molecular Interactions between Dietary Lipids and Bone Tissue during Aging.International journal of molecular sciences · 2021Review
- Bone Growth is Influenced by Fructose in Adolescent Male Mice Lacking Ketohexokinase (KHK).Calcified tissue international · 2020Article
- Bone Strength Is Improved with Genistein Treatment in Mice with Diet-Induced Obesity.Current developments in nutrition · 2019Article
- Article
- High Fructose Intake and Adipogenesis.International journal of molecular sciences · 2019Review
- Exercise prevents high fat diet-induced bone loss, marrow adiposity and dysbiosis in male mice.Bone · 2019Article
- High Fructose and High Fat Exert Different Effects on Changes in Trabecular Bone Micro-structure.The journal of nutrition, health & aging · 2018Article
- Dietary and commercialized fructose: Sweet or sour?International urology and nephrology · 2017Review
- Fat, Sugar, and Bone Health: A Complex Relationship.Nutrients · 2017Review
- Lipocalin-2 in Fructose-Induced Fatty Liver Disease.Frontiers in physiology · 2017Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Diets high in fat or carbohydrates can lead to obesity and diabetes, two interrelated conditions that have been associated with osteoporosis. Here, we contrasted the effects of a high fat (HF) versus fructose-enriched carbohydrate (CH) versus regular chow (SC) diet on bone morphology, fat content and metabolic balance in BALB/cByJ mice over a 15-week period. For 13 weeks, there were no differences in body mass between groups with small differences in the last 2 weeks. Even without the potentially confounding factor of altered body mass and levels of load bearing, HF consumption was detrimental to bone in the distal femur with lower trabecular bone volume fraction and thinner cortices than controls. These differences in bone were accompanied by twofold greater abdominal fat content and fourfold greater plasma leptin concentrations. High-fat feeding caused a decrease in de-novo lipid synthesis in the liver, kidney, white adipose and brown adipose tissue. In contrast to HF, the fructose diet did not significantly impact bone quantity or architecture. Fructose consumption also did not significantly alter leptin levels or de-novo lipid synthesis but reduced epididymal adipose tissue and increased brown adipose tissue. Cortical stiffness was lower in the CH than in HF mice. There were no differences in glucose or insulin levels between groups. Together, a diet high in fat had a negative influence on bone structure, adipose tissue deposition and lipid synthesis, changes that were largely avoided with a fructose-enriched diet.
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Registered trials
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