SynthesisHerz2017
Association between microRNA polymorphisms and coronary heart disease : A meta-analysis.
Synthesis in Herz, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.
- Association between microRNA-146a rs2910164 polymorphism and coronary heart disease: An updated meta-analysis.Medicine · 2022Pooled it
- Pooled it
- miR-146A and miR-146B Promoter Methylation and Common Sequence Variations Are Not Likely to Be Involved in Autism Spectrum Disorder.Journal of molecular neuroscience : MN · 2025Article
- Genetic variants rs2910164, rs4636297 and rs895819 may contribute to the onset of acute myocardial infarction in Pakistani population.PloS one · 2024Article
- Elevated serum miR-3129-5p contributes to the progression of coronary heart disease via targeting mTOR.The Kaohsiung journal of medical sciences · 2021Article
- Association study of miR-146a, miR-149, miR-196a2, and miR-499 polymorphisms with venous thromboembolism in a Korean population.Journal of thrombosis and thrombolysis · 2019Article
- Two Single Nucleotide Polymorphisms (rs2431697 and rs2910164) of miR-146a Are Associated with Risk of Coronary Artery Disease.International journal of environmental research and public health · 2017Article
- MiR-146a/b: a family with shared seeds and different roots.Physiological genomics · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The association between microRNA polymorphisms (miR polymorphisms) and coronary heart disease (CHD) risk has been studied intensively, but the results have been conflicting. Therefore, we conducted the present meta-analysis to obtain a more conclusive answer. We searched for eligible articles in PubMed, MEDLINE, EMBASE, Scopus, and CNKI. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to identify any potential associations. Ten case-control studies including 5,292 CHD patients and 5,446 control subjects were analyzed. The overall meta-analysis results showed that the miR-146a rs2910164 polymorphism, the miR-196a2 rs11614913 polymorphism, and the miR-499 rs3746444 polymorphism were all significantly associated with CHD risk in certain genetic models. Besides, the C allele of the miR-146a rs2910164 and miR-499 rs3746444 polymorphisms conferred increased susceptibility to CHD (C versus G, p < 0.0001, OR = 1.14, 95% CI = 1.07-1.21; p = 0.003, OR = 1.14, 95% CI = 1.05-1.25). Overall, our findings suggest that the miR-146a rs2910164, miR-196a2 rs11614913, and miR-499 rs3746444 polymorphisms may be correlated with the risk of CHD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.