ArticleJournal of biomedical optics2017
Label-free high-throughput detection and quantification of circulating melanoma tumor cell clusters by linear-array-based photoacoustic tomography.
Article in Journal of biomedical optics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Photoacoustic imaging for cutaneous melanoma assessment: a comprehensive review.Journal of biomedical optics · 2024Pooled it
- Exploiting endogenous Protoporphyrin IX for Photodynamic inactivation of Pseudomonas aeruginosa.Journal of fluorescence · 2026Article
- Considerations for the use of targeted fluorescence contrast agents to detect circulating cancer cell populations with diffuseJournal of biomedical optics · 2026Article
- Optical Microneedle-Lens Array for Selective Photothermolysis.Micromachines · 2024Article
- Android mobile-platform-based image reconstruction for photoacoustic tomography.Journal of biomedical optics · 2023Article
- Prospects for Fluorescence MolecularFrontiers in photonics · 2022Article
- Clear cell renal cell carcinoma detection by multimodal photoacoustic tomography.Photoacoustics · 2021Article
- Multiangle Long-Axis Lateral Illumination Photoacoustic Imaging Using Linear Array Transducer.Sensors (Basel, Switzerland) · 2020Article
- In vivo detection of circulating tumour cell clusters by photodiagnostic spectroscopy.Photodiagnosis and photodynamic therapy · 2020Article
- High-Resolution Photoacoustic Tomography for Early-Stage Cancer Detection and Its Clinical Translation.Radiology. Imaging cancer · 2020Review
- Label-free high-throughput photoacoustic tomography of suspected circulating melanoma tumor cells in patients in vivo.Journal of biomedical optics · 2020Article
- Snapshot Photoacoustic Topography Through an Ergodic Relay for High-throughput Imaging of Optical Absorption.Nature photonics · 2020Article
- Detection of Apoptotic Circulating Tumor Cells Using in vivo Fluorescence Flow Cytometry.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2019Article
- High-throughput, label-free, single-cell photoacoustic microscopy of intratumoral metabolic heterogeneity.Nature biomedical engineering · 2019Article
- Simultaneous acoustic and photoacoustic microfluidic flow cytometry for label-free analysis.Scientific reports · 2019Article
- Hand-held optoacoustic imaging: A review.Photoacoustics · 2018Review
- On-chip generation of microbubbles in photoacoustic contrast agents for dual modal ultrasound/photoacoustic in vivo animal imaging.Scientific reports · 2018Article
- The characterization of an economic and portable LED-based photoacoustic imaging system to facilitate molecular imaging.Photoacoustics · 2018Article
- Hand-held Clinical Photoacoustic Imaging System for Real-time Non-invasive Small Animal Imaging.Journal of visualized experiments : JoVE · 2017Article
- Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Circulating tumor cell (CTC) clusters, arising from multicellular groupings in a primary tumor, greatly elevate the metastatic potential of cancer compared with single CTCs. High-throughput detection and quantification of CTC clusters are important for understanding the tumor metastatic process and improving cancer therapy. Here, we applied a linear-array-based photoacoustic tomography (LA-PAT) system and improved the image reconstruction for label-free high-throughput CTC cluster detection and quantification <italic<in vivo</italic<. The feasibility was first demonstrated by imaging CTC cluster <italic<ex vivo</italic<. The relationship between the contrast-to-noise ratios (CNRs) and the number of cells in melanoma tumor cell clusters was investigated and verified. Melanoma CTC clusters with a minimum of four cells could be detected, and the number of cells could be computed from the CNR. Finally, we demonstrated imaging of injected melanoma CTC clusters in rats <italic<in vivo</italic<. Similarly, the number of cells in the melanoma CTC clusters could be quantified. The data showed that larger CTC clusters had faster clearance rates in the bloodstream, which agreed with the literature. The results demonstrated the capability of LA-PAT to detect and quantify melanoma CTC clusters <italic<in vivo</italic< and showed its potential for tumor metastasis study and cancer therapy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.