ArticlePloS one2016
Mitochondrial Genome Sequences and Structures Aid in the Resolution of Piroplasmida phylogeny.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 1 of them a synthesis that pooled it.
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Who cites it
74 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Global prevalence and species diversity of tick-borne pathogens in buffaloes worldwide: a systematic review and meta-analysis.Parasites & vectors · 2023Pooled it
- Comparative diagnostic performance of microscopy and PCR assays with preliminary mitochondrial sequence analysis of Babesia species infecting dogs in Jabalpur, central India.Molecular biology reports · 2026Article
- Spatial Heterogeneity of Tick-Borne Pathogens Outpaces Genetic Structuring in Anatolian Dermacentor reticulatus Populations.Transboundary and emerging diseases · 2026Article
- Molecular Survey of Hemopathogens in Dogs, Including Blood Donors, from Central-Western Brazil.Pathogens (Basel, Switzerland) · 2025Article
- Theileria lestoquardi and malignant theileriosis in small ruminants: an updated review.Tropical animal health and production · 2025Review
- Are Babesia vogeli genotypes associated with Rhipicephalus sanguineus and Rhipicephalus linnaei distribution?Parasites & vectors · 2025Article
- A survey for piroplasmids in questing Ixodes fuscipes ticks reveals undescribed Babesia lineages in Uruguay.Parasites & vectors · 2025Article
- Survey of Piroplasmids in Wild Mammals, Unconventional Pets, and Ticks from Goiás State, Midwestern Brazil.Pathogens (Basel, Switzerland) · 2025Article
- Insights into the mitochondrial genome structure and phylogenetic placement of Theileria velifera in comparison to other apicomplexan parasites.Scientific reports · 2025Article
- Molecular survey of Hepatozoon spp. and piroplasmids in rodents and marsupials from midwestern Brazil, with evidence of a novel Piroplasmida clade ("South American Rodentia") in the echimyid rodent Thrichomys pachyurus.Parasitology research · 2025Article
- Diversity ofPathogens (Basel, Switzerland) · 2025Article
- A novel genotype of Babesia microti-like group in Ixodes montoyanus ticks parasitizing the Andean bear (Tremarctos ornatus) in Ecuador.Experimental & applied acarology · 2025Article
- Diversity of piroplasmids in wild animals in Brazil: a review.Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria · 2025Review
- Genetic diversity and phylogenetic relationships of Theileria equi inferred from heat shock protein 70 kDa gene sequences in Brazilian horses.Veterinary research communications · 2024Article
- Genetic diversity of Theileria spp. in deer (Artiodactyla: Cervidae) from Brazil.Parasitology research · 2024Article
- Mitochondrial Genome Analysis ofVeterinary sciences · 2024Article
- Description ofInternational journal for parasitology. Parasites and wildlife · 2024Article
- Description and molecular characterisation of Babesia ailuropodae n. sp., a new piroplasmid species infecting giant pandas.Parasites & vectors · 2024Article
- Molecular screening and genetic diversity of tick-borne pathogens associated with dogs and livestock ticks in Egypt.PLoS neglected tropical diseases · 2024Article
- Diversity of Babesia spp. in skunks from selected states in the United States of America.Parasite (Paris, France) · 2024Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The taxonomy of the order Piroplasmida, which includes a number of clinically and economically relevant organisms, is a hotly debated topic amongst parasitologists. Three genera (Babesia, Theileria, and Cytauxzoon) are recognized based on parasite life cycle characteristics, but molecular phylogenetic analyses of 18S sequences have suggested the presence of five or more distinct Piroplasmida lineages. Despite these important advancements, a few studies have been unable to define the taxonomic relationships of some organisms (e.g. C. felis and T. equi) with respect to other Piroplasmida. Additional evidence from mitochondrial genome sequences and synteny should aid in the inference of Piroplasmida phylogeny and resolution of taxonomic uncertainties. In this study, we have amplified, sequenced, and annotated seven previously uncharacterized mitochondrial genomes (Babesia canis, Babesia vogeli, Babesia rossi, Babesia sp. Coco, Babesia conradae, Babesia microti-like sp., and Cytauxzoon felis) and identified additional ribosomal fragments in ten previously characterized mitochondrial genomes. Phylogenetic analysis of concatenated mitochondrial and 18S sequences as well as cox1 amino acid sequence identified five distinct Piroplasmida groups, each of which possesses a unique mitochondrial genome structure. Specifically, our results confirm the existence of four previously identified clades (B. microti group, Babesia sensu stricto, Theileria equi, and a Babesia sensu latu group that includes B. conradae) while supporting the integration of Theileria and Cytauxzoon species into a single fifth taxon. Although known biological characteristics of Piroplasmida corroborate the proposed phylogeny, more investigation into parasite life cycles is warranted to further understand the evolution of the Piroplasmida. Our results provide an evolutionary framework for comparative biology of these important animal and human pathogens and help focus renewed efforts toward understanding the phylogenetic relationships within the group.
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