ArticlePloS one2016
The Desire for Amputation or Paralyzation: Evidence for Structural Brain Anomalies in Body Integrity Identity Disorder (BIID).
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 36 citations in OpenAlex.
- The hidden side of body integrity dysphoria: aberrant limbic responses to dynamic touch.Brain communications · 2025Article
- One-year follow-up of amputation as a curative treatment for body integrity dysphoria: A case report.Clinical case reports · 2024Article
- Successful treatment of body integrity dysphoria with amputation: A case report.Clinical case reports · 2024Article
- Subcortical contributions to the sense of body ownership.Brain : a journal of neurology · 2024Article
- Brain Abnormalities in Individuals with a Desire for a Healthy Limb Amputation: Somatosensory, Motoric or Both? A Task-Based fMRI Verdict.Brain sciences · 2021Article
- The Bioethical Dilemma of Gender-Affirming Therapy in Children and Adolescents.The Linacre quarterly · 2021Article
- Could Brain-Computer Interface Be a New Therapeutic Approach for Body Integrity Dysphoria?Frontiers in human neuroscience · 2021Review
- An Investigation of Lower Limb Representations Underlying Vision, Touch, and Proprioception in Body Integrity Identity Disorder.Frontiers in psychiatry · 2020Article
- Mental rotation of feet in individuals with Body Integrity Identity Disorder, lower-limb amputees, and normally-limbed controls.PloS one · 2019Article
- Structural and functional hyperconnectivity within the sensorimotor system in xenomelia.Brain and behavior · 2017Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBody Integrity Identity Disorder (BIID) is a condition in which individuals perceive a mismatch between their internal body scheme and physical body shape, resulting in an absolute desire to be either amputated or paralyzed. The condition is hypothesized to be of congenital nature, but evidence for a neuro-anatomical basis is sparse.
methodsWe collected T1-weighted structural magnetic resonance imaging scans on a 3T scanner in eight individuals with BIID and 24 matched healthy controls, and analyzed the data using voxel-based morphometry.
resultsThe results showed reduced grey matter volume in the left dorsal and ventral premotor cortices and larger grey matter volume in the cerebellum (lobule VIIa) in individuals with BIID compared to controls.
conclusionThe premotor cortex and cerebellum are thought to be crucial for the experience of body-ownership and the integration of multisensory information. Our results suggest that BIID is associated with structural brain anomalies and might result from a dysfunction in the integration of multisensory information, leading to the feeling of disunity between the mental and physical body shape.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.