Evidence map›Paper›PMID 27832018›Full record

ArticleCancer nursing

Adapting an Evidence-Based Intervention to Address Targeted Therapy-Related Fatigue in Chronic Myeloid Leukemia Patients.

Hanneke Poort, Cathy D Meade, Hans Knoop, Marieke F M Gielissen, Javier Pinilla-Ibarz, Paul B Jacobsen

Open access · greenAbstract read
In one paragraph

Article in Cancer nursing. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Fatigue Related COPD From Patient's Perspectives.Journal of evaluation in clinical practice · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Hanneke PoortAuthor Affiliations: Expert Center for Chronic Fatigue, Radboud University Medical Center, Nijmegen, the Netherlands (Ms Poort and Drs Knoop and Gielissen); Division of Population Science, Department of Health Outcomes and Behavior (Drs Meade and Jacobsen), Department of Malignant Hematology (Dr Pinilla-Ibarz), H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida; Department of Medical Psychology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands (Drs Knoop and Gielissen).
Cathy D Meade
Hans Knoop
Marieke F M Gielissen
Javier Pinilla-Ibarz
Paul B Jacobsen
Exelis (United States) · US

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI KENNETH Lynn WRIGHT · 1998 to 2026
$93.5M
Internet-Assisted Cognitive Behavior Intervention for Targeted Therapy FatigueR21CA191594 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI JIM, HEATHER S.L. · 2015 to 2016
$413k
NCI NIH HHS P30 CA076292NCI NIH HHS R21 CA191594
6 · The paper itself

Abstract

backgroundFatigue is one of the most important quality of life issues experienced by patients being treated with oral targeted therapy for chronic myeloid leukemia (CML). However, no intervention exists that specifically addresses strategies to reduce targeted therapy-related fatigue.

objectiveThis study adapted an evidence-based clinic-delivered intervention (EBI) "cognitive behavior therapy for post-cancer fatigue" for use in CML patients. The existing EBI was based on 6 established perpetuating factors of fatigue (ie, sleep, activity, helpful thinking, coping with cancer, social support, and fear of disease recurrence). Study aims were to gauge reactions to (1) existing content and (2) a new Internet-assisted intervention delivery format.

methodsGuided by the ADAPT-ITT framework, we used a series of systematic steps and adaptation methodologies, including semistructured interviews with CML patients and providers and feedback from topical experts.

resultsPatients were receptive to existing content topics and an Internet-assisted delivery format was acceptable. A key theme reflected the need for a new customized psychoeducational module about CML as a disease and its treatment. Both providers and patients held positive views about the potential of the adapted EBI to improve fatigue.

conclusionsFindings offered essential guidance for the adaptation and reinforced the utility of the adapted intervention. IMPLICATIONS FOR PRACTICE: Adapting existing EBIs for new audiences contributes to advancing findings of evidence-based research, ultimately providing nurses and other healthcare providers with important referral options to interventions that may provide useful strategies to improve quality of life and reduce targeted therapy-related fatigue.

Indexed as

AdultAgedCognitive Behavioral TherapyEvidence-Based MedicineFatigueFemaleHumansLeukemia, Myelogenous, Chronic, BCR-ABL PositiveMaleMiddle AgedQuality of LifeTherapy, Computer-Assisted

Identifiers

PMID27832018
PMCPMC5422141
OpenAlexW2556922221

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.