ArticleJournal of athletic training2016
Neuromuscular Alterations After Ankle Sprains: An Animal Model to Establish Causal Links After Injury.
Article in Journal of athletic training, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- Graded ankle instability induces early osteoarthritic changes in a rat model.Osteoarthritis and cartilage open · 2026Article
- Corticospinal tract alterations after ankle sprain in adolescence: Insights from the mouse model.Sports medicine and health science · 2025Article
- Mouse model of subtalar post-traumatic osteoarthritis caused by subtalar joint instability.Journal of orthopaedic surgery and research · 2022Article
- Long-Lasting Impairments in Quadriceps Mitochondrial Health, Muscle Size, and Phenotypic Composition Are Present After Non-invasive Anterior Cruciate Ligament Injury.Frontiers in physiology · 2022Article
- Relationship between altered knee kinematics and subchondral bone remodeling in a clinically translational model of ACL injury.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Lateral Ankle Sprain in a Mouse Model: Lifelong Sensorimotor Dysfunction.Journal of athletic training · 2018Article
- Analysis for osteoarthritis of the ankle joint in a mouse model of chronic ankle instability.Science progressArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextThe mechanisms that contribute to the development of chronic ankle instability are not understood. Investigators have developed a hypothetical model in which neuromuscular alterations that stem from damaged ankle ligaments are thought to affect periarticular and proximal muscle activity. However, the retrospective nature of these studies does not allow a causal link to be established.
objectiveTo assess temporal alterations in the activity of 2 periarticular muscles of the rat ankle and 2 proximal muscles of the rat hind limb after an ankle sprain.
designControlled laboratory study.
settingLaboratory. PATIENTS OR OTHER
participantsFive healthy adult male Long Evans rats (age = 16 weeks, mass = 400.0 ± 13.5 g). INTERVENTION(S): Indwelling fine-wire electromyography (EMG) electrodes were implanted surgically into the biceps femoris, medial gastrocnemius, vastus lateralis, and tibialis anterior muscles of the rats. We recorded baseline EMG measurements while the rats walked on a motor-driven treadmill and then induced a closed lateral ankle sprain by overextending the lateral ankle ligaments. After ankle sprain, the rats were placed on the treadmill every 24 hours for 7 days, and we recorded postsprain EMG data. MAIN OUTCOME MEASURE(S): Onset time of muscle activity, phase duration, sample entropy, and minimal detectable change (MDC) were assessed and compared with baseline using 2-tailed dependent t tests.
resultsCompared with baseline, delayed onset time of muscle activity was exhibited in the biceps femoris (baseline = -16.7 ± 54.0 milliseconds [ms]) on day 0 (5.2 ± 64.1 ms; t
conclusionsManually inducing an ankle sprain in a rat by overextending the lateral ankle ligaments altered the complexity of muscle-activation patterns, and the alterations exceeded the MDC of the baseline data.
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Registered trials
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