ArticleThe British journal of nutrition2017
An investigation into the relationship between plain water intake and glycated Hb (HbA1c): a sex-stratified, cross-sectional analysis of the UK National Diet and Nutrition Survey (2008-2012).
Article in The British journal of nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Prevention and Therapy of Type 2 Diabetes-What Is the Potential of Daily Water Intake and Its Mineral Nutrients?Nutrients · 2017Pooled it
- 24 h severe fluid restriction increases a biomarker of renal injury in healthy males.European journal of applied physiology · 2025Trial
- Trial
- Effect of acute hypohydration on glycemic regulation in healthy adults: a randomized crossover trial.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Trial
- The Impact of Hydration on Metabolic Outcomes: From Arginine-Vasopressin Signaling to Clinical Implications.Medicina (Kaunas, Lithuania) · 2025Review
- Low daily water intake profile-is it a contributor to disease?Nutrition and health · 2024Review
- The association between plain water intake and periodontitis in the population aged over 45: a cross-sectional study based on NHANES 2009-2014.BMC oral health · 2024Article
- The association between water intake and future cardiometabolic disease outcomes in the Malmö Diet and Cancer cardiovascular cohort.PloS one · 2024Article
- Review
- Current Hydration Habits: The Disregarded Factor for the Development of Renal and Cardiometabolic Diseases.Nutrients · 2022Review
- THIRSTY FOR FRUCTOSE: Arginine Vasopressin, Fructose, and the Pathogenesis of Metabolic and Renal Disease.Frontiers in cardiovascular medicine · 2022Review
- Associations between urinary hydration markers and metabolic dysfunction: a cross-sectional analysis of NHANES data, 2008-2010.European journal of nutrition · 2021Article
- Water Intake and Markers of Hydration Are Related to Cardiometabolic Risk Biomarkers in Community-Dwelling Older Adults: A Cross-Sectional Analysis.The Journal of nutrition · 2021Article
- Hydration for health hypothesis: a narrative review of supporting evidence.European journal of nutrition · 2021Review
- The impact of low mineral content water on cardiac function in diabetic rats: focus on oxidative stress.Molecular and cellular biochemistry · 2020Article
- Thirst and Drinking Paradigms: Evolution from Single Factor Effects to Brainwide Dynamic Networks.Nutrients · 2019Review
- Hydration, Arginine Vasopressin, and Glucoregulatory Health in Humans: A Critical Perspective.Nutrients · 2019Review
- Fluid consumption pattern and hydration among 8-14 years-old children.European journal of clinical nutrition · 2018Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to analyse the association between plain water intake and glycated Hb (HbA1c) in the National Diet and Nutrition Survey (2008-2012) rolling survey. These data included diet (4-d diaries) and HbA1c (fasted blood sample) measures of 456 men and 579 women aged 44 (sd 18) years with full information on covariates of interest (age, ethnicity, BMI, smoking status, education, other beverage intake, energy intake and fibre). Data were analysed using sex-stratified linear and logistic regressions modelling the associations of cups per d (240 ml) of plain water with HbA1c, and odds of HbA1c≥5·5 %, respectively. Substitution analyses modelled the replacement of sugar-sweetened beverages, fruit juice and artificially sweetened beverages with plain water. After adjustment, 1 cup/d of plain water was associated with a -0·04 % lower HbA1c (95 % CI -0·07, -0·02) in men. In logistic regression, men had a 22 % (95 % CI 10, 32 %) reduced odds of HbA1c≥5·5 %/cup per d of plain water. There was no evidence of an association with either HbA1c or odds of HbA1c≥5·5 % in women. None of the substitution models was associated with a change in odds of HbA1c≥5·5 %. Plain water intake was associated with lower HbA1c in men but not in women. Substituting water for specific beverages was not associated with a reduced odds of HbA1c≥5·5 %, suggesting that the addition of water is the more pertinent factor. Future trials should test whether the relationships between water intake and HbA1c is causal as this could be a cost-effective and simple health intervention.
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