Evidence map›Paper›PMID 27830968›Full record

ArticleLeukemia & lymphoma2017

Patterns of use and survival outcomes of positron emission tomography for initial staging in elderly follicular lymphoma patients.

Ashish Rai, Loretta J Nastoupil, Jessica N Williams, Joseph Lipscomb, Kevin C Ward, David H Howard, Daniel Lee, Christopher R Flowers

Abstract read
In one paragraph

Article in Leukemia & lymphoma, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Ashish Raia Surveillance and Health Services Research Program , American Cancer Society , Atlanta , GA , USA.
Loretta J Nastoupilc Department of Lymphoma/Myeloma, Division of Cancer Medicine , The University of Texas MD Anderson Cancer Center , Houston , TX , USA.
Jessica N Williamsd Department of Hematology and Medical Oncology , Emory University School of Medicine , Atlanta , GA , USA.
Joseph Lipscombb Department of Health Policy and Management , Rollins School of Public Health, Emory University , Atlanta , GA , USA.
Kevin C Warde Department of Epidemiology , Rollins School of Public Health, Emory University , Atlanta , GA , USA.
David H Howardb Department of Health Policy and Management , Rollins School of Public Health, Emory University , Atlanta , GA , USA.
Daniel Leef Department of Radiology , Emory University School of Medicine , Atlanta , GA , USA.
Christopher R Flowersg Department of Hematology and Medical Oncology , Winship Cancer Institute, Emory University , Atlanta , GA , USA.

Funding

Mentored Patient Oriented Research in LymphomaK24CA208132 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI FLOWERS, CHRISTOPHER R · 2016 to 2020
$822k
Biological Variants Underlying Racial Differences in LymphomaR21CA158686 · NCI · EMORY UNIVERSITY · PI FLOWERS, CHRISTOPHER R · 2012 to 2013
$371k
NCI NIH HHS K24 CA208132NCI NIH HHS R21 CA158686
6 · The paper itself

Abstract

The role of positron emission tomography (PET) in the initial assessment of follicular lymphoma (FL) has been a topic of debate. We examined the patterns of utilization of PET staging in FL and assessed the association of PET with survival. Using the SEER-Medicare database, we identified 5712 patients diagnosed with first primary FL between 2000 and 2009. Older age, African-American race, poor performance status, B-symptoms and history of anemia were negatively associated with PET staging. Receipt of PET staging was positively associated with treatment at institutions affiliated with research networks and with residence in areas with higher concentrations of nuclear medicine specialists. PET was associated with improved lymphoma-related (HR 0.69, 95% CI: 0.58-0.82) and overall (HR 0.75, 95% CI: 0.68-0.83) survival. Our findings substantiate the use of PET as the standard of care for imaging in FL patients. Further investigation is warranted to identify mechanisms underlying the apparent survival advantage associated with PET staging in FL.

Indexed as

Positron-Emission TomographyPractice Patterns, Physicians'AgedAged, 80 and overComorbidityFemaleFluorodeoxyglucose F18HumansKaplan-Meier EstimateLymphoma, FollicularMaleNeoplasm StagingPopulation SurveillancePositron Emission Tomography Computed TomographyPrognosisProportional Hazards ModelsFluorodeoxyglucose F18follicular lymphomaneoplasm stagingpatterns of carePositron emission tomography

Identifiers

PMID27830968
PMCPMC5726977

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.