Evidence map›Paper›PMID 27830836›Full record

Trial reportScientific reports2016

Long-term lifestyle interventions in middle-aged and elderly men with nonalcoholic fatty liver disease: a randomized controlled trial.

Fangyuan Dong, Yan Zhang, Yiqin Huang, Yiqian Wang, Gansheng Zhang, Xiaona Hu, Jiaofeng Wang, Jie Chen, Zhijun Bao

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04450875 (Efficacy of Nutritional Therapy With High Methionine Content in the Treatment of Non-alcoholic Fatty Liver), which is not on this map. Cited by 29 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 10 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04450875 nacompletednot on this map

Efficacy of Nutritional Therapy With High Methionine Content in the Treatment of Non-alcoholic Fatty Liver: a Randomized Clinical Trial

TypeinterventionalSponsorUniversidad VeracruzanaRan2015 to 2017Enrolled121ConditionsNon-alcoholic Fatty Liver Disease (NAFLD)ArmsExperimental group (with diet)
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 10 syntheses or guidelines pooled it, 59 citations in OpenAlex.

  1. Pooled it
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  7. A systematic review examining socioeconomic factors in trials of interventions for men that report weight as an outcome.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022
    Pooled it
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  11. Review
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  17. Targeting ketone body metabolism to treat fatty liver disease.Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Fangyuan DongDepartment of Gastroenterology, Huadong Hospital, Shanghai Medical College, Fudan University, No. 221 Yan'an West Road, Shanghai 200040, P.R. China.
Yan ZhangShanghai Key Laboratory of Clinical Geriatric Medicine, No. 221 Yan'an West Road, Shanghai 200040, P.R. China.
Yiqin HuangDepartment of Gastroenterology, Huadong Hospital, Shanghai Medical College, Fudan University, No. 221 Yan'an West Road, Shanghai 200040, P.R. China.
Yiqian WangDepartment of Gastroenterology, Huadong Hospital, Shanghai Medical College, Fudan University, No. 221 Yan'an West Road, Shanghai 200040, P.R. China.
Gansheng ZhangDepartment of Gastroenterology, Huadong Hospital, Shanghai Medical College, Fudan University, No. 221 Yan'an West Road, Shanghai 200040, P.R. China.
Xiaona HuDepartment of Gastroenterology, Huadong Hospital, Shanghai Medical College, Fudan University, No. 221 Yan'an West Road, Shanghai 200040, P.R. China.
Jiaofeng WangShanghai Key Laboratory of Clinical Geriatric Medicine, No. 221 Yan'an West Road, Shanghai 200040, P.R. China.
Jie ChenDepartment of Gastroenterology, Huadong Hospital, Shanghai Medical College, Fudan University, No. 221 Yan'an West Road, Shanghai 200040, P.R. China.
Zhijun BaoDepartment of Gastroenterology, Huadong Hospital, Shanghai Medical College, Fudan University, No. 221 Yan'an West Road, Shanghai 200040, P.R. China.
Huadong Hospital · CNFudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nonalcoholic fatty liver disease (NAFLD), a metabolic disorder related to insulin resistance and metabolic syndrome, has become a public health concern. Currently, the principal therapeutic modalities targeting NAFLD are lifestyle interventions. However, the efficacy of long-term lifestyle interventions in managing NAFLD remains largely unexplored. This study aimed to evaluate the efficacy of long-term lifestyle interventions in middle-aged and elderly men with NAFLD. All 280 eligible patients were randomized to the control or test group. Patients in the test group received counseling on diet and exercise from 2 physicians every 3 months via a phone call. Patients in the control group received only counseling in annual checkups without regular intervention. After the 2-year periodic intervention, body weight, abdominal circumference, ALT, TCH, LDL-C and HDL-C decreased in the test group. Specifically, the fatty liver index (FLI) and NAFLD-fibrosis score (NAFLD-FS) reduced markedly in the test group. However, in the control group, there was only a significant decrease in LDL-C, HDL-C and NAFLD-FS (P < 0.001). The liver steatosis grade of the test group decreased significantly, while it increased in the control group. In NAFLD, long-term lifestyle interventions exert an anti-obesity effect and attenuate liver dysfunction and steatosis.

Indexed as

Health BehaviorHumansLife StyleLiverMaleMiddle AgedNon-alcoholic Fatty Liver DiseaseTreatment Outcome

Identifiers

PMID27830836
PMCPMC5103187
OpenAlexW2551962041

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.