ArticleScientific reports2016
Effects of weaning on intestinal crypt epithelial cells in piglets.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 64 citations in OpenAlex.
- Role of gut microbiota metabolites in maintaining intestinal health and preventing weaning-associated diarrhea in piglets.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Review
- Dual-action peptide KWHVeterinary research · 2026Article
- Synbiotic Diet PreventsCurrent issues in molecular biology · 2026Article
- Age-dependent functional and transcriptional differences in intestinal mesenchymal stromal cells during early postnatal development in piglets.Frontiers in cell and developmental biology · 2026Article
- Integrated Transcriptome and Metabolome Analysis of the Porcine Small Intestine During Weaning.Genes · 2025Article
- Growth performance and total tract digestibility of nutrients for weanling pigs are improved by an exogenous xylanase and a stimbiotic regardless of maternal xylanase consumption.Journal of animal science and biotechnology · 2025Article
- Effects of probiotics on growth performance, intestinal morphology, intestinal microbiota weaning pig challenged withJournal of animal science and technology · 2025Article
- New insights into the unfolded protein response (UPR)-anterior gradient 2 (AGR2) pathway in the regulation of intestinal barrier function in weaned piglets.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2023Review
- Early feeding leads to molecular maturation of the gut mucosal immune system in suckling piglets.Frontiers in immunology · 2023Article
- Early weaning leads to the remodeling of lipid profile in piglet jejunal crypt cells during post-weaning days.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Article
- Review
- Article
- Weaning stress and intestinal health of piglets: A review.Frontiers in immunology · 2022Review
- Importance of Zinc Nanoparticles for the Intestinal Microbiome of Weaned Piglets.Frontiers in veterinary science · 2022Review
- Effects ofJournal of animal science and technology · 2021Article
- Effects of Dietary Supplementation of gEGF on the Growth Performance and Immunity of Broilers.Animals : an open access journal from MDPI · 2021Article
- Effects of varying dietary folic acid during weaning stress of piglets.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2021Article
- Friend or Foe? Impacts of Dietary Xylans, Xylooligosaccharides, and Xylanases on Intestinal Health and Growth Performance of Monogastric Animals.Animals : an open access journal from MDPI · 2021Review
- Dietary Glutamic Acid Modulates Immune Responses and Gut Health of Weaned Pigs.Animals : an open access journal from MDPI · 2021Article
- Effects of Dietary Energy Levels on Rumen Fermentation, Gastrointestinal Tract Histology, and Bacterial Community Diversity in Fattening Male Hu Lambs.Frontiers in microbiology · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intestinal epithelial cells in the crypt proliferate in piglets in response to weaning. However, the underlying mechanism has been unclear. We examined 40 piglets from eight litters (five piglets per litter) that were weaned at the age of 14 d, and one piglet from each litter was randomly selected for closer investigation. Based on the distended intestinal sac method, we isolated crypt epithelial cells from the mid-jejunum on Days 0, 1, 3, 5, and 7 post-weaning. Protein expression was analyzed using either isobaric tags for relative and absolute quantification or western blotting. Proteins related to the cell cycle, organization of the cellular macromolecular complex subunit, localization of cellular macromolecules, Golgi vesicle transport, fatty acid metabolism, oxidative phosphorylation, and translational initiation were mainly down-regulated, while those involved in glycolysis, cell cycle arrest, protein catabolism, and cellular amino acid metabolism were up-regulated. The amount of proteins active in the mTOR signaling pathway was generally decreased over time. These results indicate that weaning influences energy metabolism, cellular macromolecule organization and localization, and protein metabolism, thereby affecting the proliferation of intestinal epithelial cells in weaned piglets. Moreover, those cellular processes are possibly controlled by that signaling pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.