Evidence map›Paper›PMID 27830722›Full record

Trial reportScientific reports2016

Comprehensive polymerase chain reaction assay for detection of pathogenic DNA in lymphoproliferative disorders of the ocular adnexa.

Yoshihiko Usui, Narsing A Rao, Hiroshi Takase, Kinya Tsubota, Kazuhiko Umazume, Daniel Diaz-Aguilar, Takeshi Kezuka, Manabu Mochizuki, Hiroshi Goto, Sunao Sugita

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Involvement of Helicobacter Pylori in Ocular Adnexa Lymphoma.Pathology oncology research : POR · 2020
    Pooled it
  2. Article
  3. Article
  4. Etiological analysis of ocular herpes virus infection.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. [Research progress on etiologic diagnosis of ocular viral diseases].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2020
    Review
  11. Article
  12. Review
  13. Lymphoproliferative Syndromes Associated with Human Herpesvirus-6A and Human Herpesvirus-6B.Mediterranean journal of hematology and infectious diseases · 2018
    Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Yoshihiko UsuiDepartment of Ophthalmology, Tokyo Medical University, Tokyo, Japan.
Narsing A RaoDepartment of Ophthalmology, University of Southern California, USA.
Hiroshi TakaseDepartment of Ophthalmology &Visual Science, Tokyo Medical and Dental University, Tokyo, Japan.
Kinya TsubotaDepartment of Ophthalmology, Tokyo Medical University, Tokyo, Japan.
Kazuhiko UmazumeDepartment of Ophthalmology, Tokyo Medical University, Tokyo, Japan.
Daniel Diaz-AguilarDavid Geffen School of Medicine, University of California, 10833 Le Conte Ave, Los Angeles, CA 90095.
Takeshi KezukaDepartment of Ophthalmology, Tokyo Medical University, Tokyo, Japan.
Manabu MochizukiDepartment of Ophthalmology &Visual Science, Tokyo Medical and Dental University, Tokyo, Japan.
Hiroshi GotoDepartment of Ophthalmology, Tokyo Medical University, Tokyo, Japan.
Sunao SugitaLaboratory for Retinal Regeneration, RIKEN Center for Developmental Biology, Kobe, Japan.
Tokyo Medical University · JPTokyo Medical and Dental University · JPRIKEN Center for Biosystems Dynamics Research · JPUniversity of California, Los Angeles · USUniversity of Southern California · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infectious agents have been identified as a major cause of specific types of human cancers worldwide. Several microorganisms have been identified as potential aggravators of ocular adnexal neoplasms; however, given the rarity of these neoplasms, large epidemiological studies are difficult to coordinate. This study aimed to conduct an exhaustive search for pathogenic DNA in lymphoproliferative disorders (LPD) of the ocular adnexa in a total of 70 patients who were diagnosed with LPD of the ocular adnexa between 2008 and 2013. Specimens were screened for bacterial, viral, fungal, and parasitic DNA by multiplex polymerase chain reaction (PCR) and quantitative real-time PCR. Among cases of conjunctival mucosa-associated lymphoid tissue lymphoma, human herpes virus (HHV)-6, HHV-7, chlamydia, Epstein-Barr virus (EBV) and bacterial 16S ribosomal DNA were detected. In cases of IgG4-related ocular disease, similar pathogens were detected but in a larger number of patients. Our PCR assays detected DNAs of various infectious agents in tumor specimens, especially HHV6, HHV7, and EBV, with different positive rates in various types of LPD. Chronic inflammatory stimulation or activation of oncogenes from these infectious agents might be involved in the pathogenesis of LPD of the ocular adnexa.

Indexed as

Lymphoproliferative DisordersAdultAgedChlamydiaDNA, BacterialDNA, ViralEye DiseasesFemaleHerpesviridaeHumansMaleMiddle AgedMultiplex Polymerase Chain ReactionDNA, BacterialDNA, Viral

Identifiers

PMID27830722
PMCPMC5103257
OpenAlexW2555294053

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.