Evidence map›Paper›PMID 27830532›Full record

ReviewMolecular neurobiology2017

Role of Microglia in Neurological Disorders and Their Potentials as a Therapeutic Target.

Li Du, Ying Zhang, Yang Chen, Jie Zhu, Yi Yang, Hong-Liang Zhang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular neurobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 153 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
153citing papers in PubMed, 2 pooled it
13.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

153 citing papers in PubMed, 2 syntheses or guidelines pooled it, 265 citations in OpenAlex.

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93 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Li DuNeuroscience Center, Department of Neurology, The First Hospital of Jilin University, Jilin University, Xinmin Street 71#, Changchun, 130021, China.
Ying ZhangNeuroscience Center, Department of Neurology, The First Hospital of Jilin University, Jilin University, Xinmin Street 71#, Changchun, 130021, China.
Yang ChenNeuroscience Center, Department of Neurology, The First Hospital of Jilin University, Jilin University, Xinmin Street 71#, Changchun, 130021, China.
Jie ZhuNeuroscience Center, Department of Neurology, The First Hospital of Jilin University, Jilin University, Xinmin Street 71#, Changchun, 130021, China.
Yi YangNeuroscience Center, Department of Neurology, The First Hospital of Jilin University, Jilin University, Xinmin Street 71#, Changchun, 130021, China. doctoryangyi@163.com.
Hong-Liang ZhangNeuroscience Center, Department of Neurology, The First Hospital of Jilin University, Jilin University, Xinmin Street 71#, Changchun, 130021, China. drzhl@hotmail.com.ORCID 0000-0002-2916-1014
Jilin University · CNNational Natural Science Foundation of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microglia are resident macrophage-like immune cells in the central nervous system (CNS) and play a vital role in both physiological and pathological conditions, including restoring the integrity of the CNS and promoting the progression of neurodegenerative disorders. Upon stimulation, microglia typically convert from a surveillant to an activated phenotype. The major function of microglia is to maintain homeostasis and normal function of the CNS, both during development and in response to CNS injury. Microglia regulate multiple aspects of inflammation, such as repair, cytotoxicity, regeneration, and immunosuppression due to their different kind of activation states or phenotypes. Although microglia are involved in almost all neurodegenerative disorders, the mechanisms for microglial activation and their potential contributions to neuronal degeneration remain a matter of intense debate. In inflammatory process of the CNS, polarized M1 microglia can produce proinflammatory cytokines, neurotoxic molecules, which contribute to dysfunction of neural network and promoting inflammation reaction, whereas polarized M2 microglia secrete antiinflammatory mediators and neurotrophic factors that are involved in restoring homeostasis. Modulation of microglial activation for therapeutic purposes might be realized via suppressing the deleterious effects of these cells, while simultaneously retaining their protective functions. Here, we summarize the functions of microglia and discuss dual role of microglia in neurodegenerative diseases as well as multiple sclerosis.

Indexed as

AnimalsHumansInflammation MediatorsMicrogliaNerve Growth FactorsNervous System DiseasesNeuroprotective AgentsInflammation MediatorsNerve Growth FactorsNeuroprotective AgentsInflammationM1/M2 polarizationMicrogliaMicroglial activationNeurodegenerative disorders

Identifiers

PMID27830532
OpenAlexW2552476469

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.