Trial reportSurgery today2017
Haloperidol prophylaxis for preventing aggravation of postoperative delirium in elderly patients: a randomized, open-label prospective trial.
Trial report in Surgery today, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Pooled it
- The effect of haloperidol's perioperative application on postoperative delirium in elderly patients: a systematic review and meta-analysis.BMC anesthesiology · 2024Pooled it
- Effects of Haloperidol on Delirium in Adult Patients: A Systematic Review and Meta-Analysis.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2018Pooled it
- Strategies to prevent postoperative delirium: a comprehensive evaluation of anesthesia selection and drug intervention.Frontiers in psychiatry · 2024Review
- Management of a trauma patient with alcohol withdrawal who developed neuroleptic malignant syndrome in Korea: a case report.Journal of trauma and injury · 2023Article
- Mechanical Bowel Preparation Is a Risk Factor for Postoperative Delirium as It Alters the Gut Microbiota Composition: A Prospective Randomized Single-Center Study.Frontiers in aging neuroscience · 2022Article
- Review
- Related Factors and Treatment of Postoperative Delirium in Old Adult Patients: An Integrative Review.Healthcare (Basel, Switzerland) · 2021Review
- Comparative effectiveness of pharmacological interventions to prevent postoperative delirium: a network meta-analysis.Scientific reports · 2021Article
- Antipsychotic Drugs in Prevention of Postoperative Delirium-What Is Known in 2020?International journal of environmental research and public health · 2020Review
- American Society for Enhanced Recovery and Perioperative Quality Initiative Joint Consensus Statement on Postoperative Delirium Prevention.Anesthesia and analgesia · 2020Article
- Risk factors and measures of pulmonary complications after thoracoscopic esophagectomy for esophageal cancer.Surgery today · 2019Article
- An update on postoperative delirium: Clinical features, neuropathogenesis, and perioperative management.Current anesthesiology reports · 2018Article
- Clinical benefits of single-incision laparoscopic surgery for postoperative delirium in elderly colon cancer patients.Surgical endoscopy · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposesThe aim of this study was to evaluate the safety and efficacy of the early administration haloperidol in preventing the aggravation of postoperative delirium in elderly patients.
methodsA total of 201 patients (age ≥75 years) who underwent elective surgery were enrolled. The patients were divided into two groups: the intervention group (n = 101) received prophylactic haloperidol (5 mg); the control group (n = 100) did not. Haloperidol was administered daily during postoperative days 0-5 to the patients who presented with NEECHAM scores of 20-24 when measured at 18:00. The primary endpoint was the incidence of severe postoperative delirium.
resultsThe incidence of severe postoperative delirium in all patients was 25.1%. The incidence of severe postoperative delirium in the intervention group (18.2%) was significantly lower than that in the control group (32.0%) (p = 0.02). The difference between the two groups was larger when the analysis was limited to the 70 patients who had NEECHAM scores of 20-24 for at least one day during postoperative days 0-5. No adverse effects of the haloperidol were observed.
conclusionThe prophylactic administration of haloperidol at the early stage of delirium significantly reduced the incidence of severe postoperative delirium in elderly patients. Clinical Trial Registration UMIN000007204.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.