Evidence map›Paper›PMID 27830357›Full record

Trial reportMetabolic brain disease2017

Effects of ulinastatin on early postoperative cognitive function after one-lung ventilation surgery in elderly patients receiving neoadjuvant chemotherapy.

Kai-Yuan Wang, Quan-Yong Yang, Peng Tang, Hui-Xia Li, Hong-Wei Zhao, Xiu-Bao Ren

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Metabolic brain disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 3 pooled it
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Kai-Yuan WangDepartment of Anesthesiology, Tianjin Medical University Cancer Institute and Hospital, Tiyuanbei, Tianjin, China.
Quan-Yong YangDepartment of Anesthesiology, Tianjin Medical University Cancer Institute and Hospital, Tiyuanbei, Tianjin, China.
Peng TangNational Clinical Research Center for Cancer, Tianjin, China.
Hui-Xia LiNational Clinical Research Center for Cancer, Tianjin, China.
Hong-Wei ZhaoDepartment of Anesthesiology, Tianjin Medical University Cancer Institute and Hospital, Tiyuanbei, Tianjin, China. mazuiys@126.com.
Xiu-Bao RenNational Clinical Research Center for Cancer, Tianjin, China. renxbtjmu@163.com.
Tianjin Medical University Cancer Institute and Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigated the effects of ulinastatin on early postoperative cognitive dysfunction (POCD) after one-lung ventilation (OLV) surgery in elderly patients receiving neoadjuvant chemotherapy. Eighty elderly patients with preoperative neoadjuvant chemotherapy scheduling for radical esophagectomy under OLV were recruited. They were randomly divided into an ulinastatin pretreatment group (U group, n = 40) and a control group (C group, n = 40). The U group received 10,000 U/kg ulinastatin before anesthesia and 5000 U/kg daily on postoperative days 1 to 3, while C group received saline. Levels of interleukin (IL)-6, IL-10, C-reactive protein (CRP), and S-100β protein were assayed before surgery, at the end of surgery, and on postoperative days 1 and 3. Patients underwent cognitive assessment 1 day before and 7 days after surgery. 38 patients in U group and 37 patients in C group completed the neuropsychological tests. The U group had a lower incidence of POCD than C group (23.7 % versus 45.9 %, P = 0.043). The levels of S-100β protein, IL-6, IL-10, and CRP in both groups increased after surgery. The postoperative concentrations of S-100β protein, IL-6, and CRP in U group were lower than those in C group. On postoperative day 3, compared with C group, the level of CRP in U group was lower, while that of IL-10 was higher. These findings demonstrate that ulinastatin can attenuate the elevation of S100β protein levels and the incidence of POCD, most likely by the mechanism of reducing serum IL-6 and CRP levels and increasing IL-10 levels.

Indexed as

AgedAged, 80 and overCognition DisordersCytokinesEsophagectomyFemaleGlycoproteinsHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleNeoadjuvant TherapyNeuropsychological TestsOne-Lung VentilationPostoperative ComplicationsS100 Calcium Binding Protein beta SubunitCytokinesGlycoproteinsHydroxymethylglutaryl-CoA Reductase InhibitorsS100 Calcium Binding Protein beta SubuniturinastatinAdjuvantChemotherapyCognitionOne-lung ventilationUlinastatin

Identifiers

PMID27830357
OpenAlexW2549347365

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.