ArticleIndian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine2016
Pseudocholinesterase as a predictor of mortality and morbidity in organophosphorus poisoning.
Article in Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 23 citations in OpenAlex.
- Acute organophosphorus toxicity in a regional hospital in Johannesburg, South Africa: A retrospective chart review.African journal of emergency medicine : Revue africaine de la medecine d'urgence · 2023Article
- Dichlorvos Poisoning: A Mystery Case of Distributive Shock Unraveling with Atropine.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2021Article
- Caspases as prognostic markers and mortality predictors in acute organophosphorus poisoning.Journal, genetic engineering & biotechnology · 2020Article
- Manifestations of and risk factors for acute myocardial injury after acute organophosphorus pesticide poisoning.Medicine · 2019Observational
- Effects of IL-10 on OX62, MHC-II and CD86 in bone marrow DCs in rats with organophosphate poisoning.Experimental and therapeutic medicine · 2018Article
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
backgroundOrganophosphorus (OP) pesticide poisoning is a major clinical and public health problem in India. Mortality rate remains high at 15%-30%.
aimsThis prospective, observational study examines the relationship between pseudocholinesterase (PChE) activity and morbidity and mortality in OP poisoning. SETTING AND
designOP poisoning cases admitted to a tertiary care center Intensive Care Unit (ICU) over 5 years from 2010 to 2014 were studied.
methodsPatients <16 years of age, those on steroids and those with neuromuscular weakness, were excluded from the study. Serum PChE level at admission was estimated and the severity of poisoning assessed accordingly. Primary outcome measures were ICU length of stay and ventilator-free days. Secondary outcome measures included vasopressor-free days, amount of atropine given, hospital length of stay, and ICU mortality.
resultsThere were 37 patients included in the study, aged between 24 and 44 years, of which 65% were male. They were divided into two groups according to PChE levels. Group A with PChE levels more than 1000 IU/L had twenty patients and Group B with levels <1000 IU/L had 17 patients. Group B had longer ICU length of stay (
conclusionsPChE level at presentation is a reliable indicator of the severity of OP poisoning and a predictor of the need for mechanical ventilation and the duration of stay in the ICU.
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