ArticleJournal of neurogastroenterology and motility2017
Chronic Early-life Stress in Rat Pups Alters Basal Corticosterone, Intestinal Permeability, and Fecal Microbiota at Weaning: Influence of Sex.
Article in Journal of neurogastroenterology and motility, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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Who cites it
66 citing papers in PubMed, 124 citations in OpenAlex.
- The effect of a mindfulness-based therapy on different biomarkers among patients with inflammatory bowel disease: a randomised controlled trial.Scientific reports · 2020Trial
- Balancing inflammation under stress: glucocorticoid regulation of innate immune pathways.Bioscience reports · 2026Review
- Early growth restriction disrupts mice intestinal clock and homeostasis without being prevented by lactoferrin.Pediatric research · 2026Article
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- Early life stress and the pathogenesis of visceral hypersensitivity: mechanisms and implications for disorders of gut-brain interaction.Frontiers in cell and developmental biology · 2026Review
- Impact of Sex, Gonadectomy, and Repeated Restraint Stress on Gut Microbiome in Mice.Molecular neurobiology · 2025Article
- Enteric neuropathy and the vagus nerve: Therapeutic implications.Neurogastroenterology and motility · 2025Review
- Gut-Brain Axis a Key Player to Control Gut Dysbiosis in Neurological Diseases.Molecular neurobiology · 2024Review
- Sex specific gut-microbiota signatures of resilient and comorbid gut-brain phenotypes induced by early life stress.Neurobiology of stress · 2024Article
- Altered Gut Microbiota Patterns in Young Children with Recent Maltreatment Exposure.Biomolecules · 2024Article
- Modulation of gut microbiota composition due to early weaning stress induces depressive behavior during the juvenile period in mice.Animal microbiome · 2024Article
- Microbial and Metabolite Signatures of Stress Reactivity in Ulcerative Colitis Patients in Clinical Remission Predict Clinical Flare Risk.Inflammatory bowel diseases · 2024Article
- Adverse effects of early-life stress: focus on the rodent neuroendocrine system.Neural regeneration research · 2024Review
- Experiences of discrimination are associated with microbiome and transcriptome alterations in the gut.Frontiers in microbiology · 2024Article
- Chronic Stress in Early Development and Effects on Traumatic Brain Injury Outcome.Advances in neurobiology · 2024Review
- Review
- Adverse childhood experiences and obesity linked to indicators of gut permeability and inflammation in adult women.Physiology & behavior · 2023Article
- Prebiotic Supplementation during Lactation Affects Microbial Colonization in Postnatal-Growth-Restricted Mice.Nutrients · 2023Article
- Stress, inflammation, microbiome and depression.Pharmacology, biochemistry, and behavior · 2023Review
- Effect of developmental stress on theFrontiers in psychiatry · 2023Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND/
aimsWistar rat dams exposed to limited nesting stress (LNS) from post-natal days (PND) 2 to 10 display erratic maternal behavior, and their pups show delayed maturation of the hypothalamic-pituitary-adrenal axis and impaired epithelial barrier at PND10 and a visceral hypersensitivity at adulthood. Little is known about the impact of early life stress on the offspring before adulthood and the influence of sex. We investigated whether male and female rats previously exposed to LNS displays at weaning altered corticosterone, intestinal permeability, and microbiota.
methodsWistar rat dams and litters were maintained from PND2 to 10 with limited nesting/bedding materials and thereafter reverted to normal housing up to weaning (PND21). Control litters had normal housing. At weaning, we monitored body weight, corticosterone plasma levels (enzyme immunoassay), in vivo intestinal to colon permeability (fluorescein isothiocyanate-dextran 4 kDa) and fecal microbiota (DNA extraction and amplification of the V4 region of the 16S ribosomal RNA gene).
resultsAt weaning, LNS pups had hypercorticosteronemia and enhanced intestinal permeability with females > males while body weights were similar. LNS decreased fecal microbial diversity and induced a distinct composition characterized by increased abundance of Gram positive cocci and reduction of fiber-degrading, butyrate-producing, and mucus-resident microbes.
conclusionsThese data indicate that chronic exposure to LNS during the first week post-natally has sustained effects monitored at weaning including hypercorticosteronemia, a leaky gut, and dysbiosis. These alterations may impact on the susceptibility to develop visceral hypersensitivity in adult rats and have relevance to the development of irritable bowel syndrome in childhood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.