SynthesisBMC musculoskeletal disorders2016
Autologous bone graft in the treatment of post-traumatic bone defects: a systematic review and meta-analysis.
Synthesis in BMC musculoskeletal disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed, 2 syntheses or guidelines pooled it, 153 citations in OpenAlex.
- 3D Printing of Bone Substitutes Based on Vat Photopolymerization Processes: A Systematic Review.Journal of tissue engineering and regenerative medicine · 2023Pooled it
- The Induced Membrane Technique for the Management of Segmental Tibial Defect or Nonunion: A Systematic Review and Meta-Analysis.BioMed research international · 2020Pooled it
- Novel parathyroid hormone-based bone graft substitute, KUR-111, in treatment of tibial plateau fractures: a prospective, randomised, open-label, multicenter study.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2026Trial
- Autologous Iliac Bone Graft Compared with Biphasic Hydroxyapatite and Calcium Sulfate Cement for the Treatment of Bone Defects in Tibial Plateau Fractures: A Prospective, Randomized, Open-Label, Multicenter Study.The Journal of bone and joint surgery. American volume · 2020Trial
- [One-stage debridement and internal fixation exchange combined with continuous local antibiotic irrigation in treatment of fracture-related infection].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026Article
- Article
- Strategic considerations in the treatment of infected nonunion in the lower extremity: a narrative review.International journal of surgery (London, England) · 2026Article
- Recent advances in biomaterials for bone regeneration: Bridging innovation and clinical translation.Materials today. Bio · 2026Review
- Bone-Healing Enhancement Using Particulate Biomaterials and Fibrin-Based Compounds: A Narrative Literature Review of Evidence in Animal Models.Materials (Basel, Switzerland) · 2026Review
- Osteogenic Differentiation Properties of BLGFs/ODEX Hydrogel Doped With Collagen Derived FromInternational journal of biomaterials · 2026Article
- Biocompatible Thermoplastics in Additive Manufacturing of Bone Defect Fillers: State-of-the-Art and Future Prospects.Materials (Basel, Switzerland) · 2025Review
- Bone transport combined with internal fixation in post-traumatic distal humerus defects and nonunions: retrospective analysis of 16 patients.Journal of orthopaedic surgery and research · 2025Article
- Reconstruction of a large distal femoral giant cell tumor using a 3D-printed condylar support lattice metal implant and fibular grafts: a novel biomechanical and surgical approach.3D printing in medicine · 2025Article
- [Free latissimus dorsi myocutaneous flap transplantation combined with external fixation for bone and soft tissue defects around knee joint].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2025Article
- A novel classification for aseptic femoral shaft nonunion after intramedullary nailing: a retrospective study.BMC musculoskeletal disorders · 2025Article
- 3D-printed prosthesis for traumatic trapezium bone defect: a case report.Archives of orthopaedic and trauma surgery · 2025Article
- Versatility of Vascularized Fibular Graft in Forearm Bone Loss: From Initial Treatment to Secondary Nonunion Treatment.Journal of hand surgery global online · 2025Article
- The histopathologic evaluation of local effects of ozone therapy on the healing of experimental calvarial defects of rats.BMC oral health · 2025Article
- Locking compression plate as a sequential external fixator following the distraction phase for the treatment of tibial bone defects caused by fracture-related infection: experiences from 22 cases.BMC musculoskeletal disorders · 2024Article
- Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis meta-analysis aimed to determine the bone union rate of bone defects treated with the different autologous bone graft techniques.
methodsThe PubMed and the Cochrane Library databases were searched using the terms: 'fracture' AND ('bone loss' OR 'defect' OR 'defects') AND 'bone graft', restricted to English language, to human species, and to a publication period from January 1999 to November 2014. Data were extracted by one of the reviewers and then checked by the second. A quality of evidence score and a methodology score were used. Heterogeneity was assessed. A random effects model approach was used to combine estimates.
resultsOut of 376 selected studies only 34 met the inclusion criteria. The summary pooled union rate was 91 % (95 % CI: 87-95 %) while union rate after additional procedures raised to 98 % (95 % CI 96-99 %). No association between union rate and bone defect size was found. (Univariable regression model: vascularized: P = 0.677; non-vascularized: 0.202. Multivariable regression model: vascularized: P = 0.381; non-vascularized: P = 0.226). Vascularized graft was associated with a lower risk of infection after surgery when compared to non-vascularized graft (95 % CI 0.03 to 0.23, p < 0.001).
conclusionThe results of this meta-analysis demonstrate the effectiveness of autologous graft for bone defects. Furthermore, from the available clinical evidence bone defect size does not seem to have an impact on bone union when treated with autologous bone graft techniques.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.