ArticleReproductive biology and endocrinology : RB&E2016
Characterization of exosomal release in bovine endometrial intercaruncular stromal cells.
Article in Reproductive biology and endocrinology : RB&E, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 46 citations in OpenAlex.
- Regulatory roles of extracellular vesicles in pregnancy complications.Journal of advanced research · 2025Review
- Exosomal crosstalk: the metastatic language of hepatocellular carcinoma.Frontiers in immunology · 2025Review
- Altered microRNA composition in the uterine lumen fluid in cattle (Bos taurus) pregnancies initiated by artificial insemination or transfer of an in vitro produced embryo.Journal of animal science and biotechnology · 2024Article
- Urinary Extracellular Vesicles for Non-Invasive Quantification of Principal Cell Damage in Kidney Transplant Recipients.Biomolecules · 2024Article
- Sex and fetal genome influence gene expression in pig endometrium at the end of gestation.BMC genomics · 2024Article
- Current knowledge on the role of extracellular vesicles in endometrial receptivity.European journal of medical research · 2023Review
- Decidual derived exosomal miR-99a-5p targets Ppp2r5a to inhibit trophoblast invasion in response to CeOParticle and fibre toxicology · 2023Article
- Article
- Immune Tolerance of Embryo Implantation and Pregnancy: The Role of Human Decidual Stromal Cell- and Embryonic-Derived Extracellular Vesicles.International journal of molecular sciences · 2022Review
- Uterine extracellular vesicles as multi-signal messengers during maternal recognition of pregnancy in the mare.Scientific reports · 2022Article
- Low-Dose Tacrolimus Promotes the Migration and Invasion and Nitric Oxide Production in the Human-Derived First Trimester Extravillous Trophoblast Cells In Vitro.International journal of molecular sciences · 2022Article
- The role of extracellular vesicles in animal reproduction and diseases.Journal of animal science and biotechnology · 2022Review
- A Comparison of Blood Plasma Small Extracellular Vesicle Enrichment Strategies for Proteomic Analysis.Proteomes · 2022Article
- Exosome Carrier Effects; Resistance to Digestion in Phagolysosomes May Assist Transfers to Targeted Cells; II Transfers of miRNAs Are Better Analyzed via Systems Approach as They Do Not Fit Conventional Reductionist Stoichiometric Concepts.International journal of molecular sciences · 2022Review
- Hypoxia Induced Changes of Exosome Cargo and Subsequent Biological Effects.Frontiers in immunology · 2022Review
- Exosomes as Naturally Occurring Vehicles for Delivery of Biopharmaceuticals: Insights from Drug Delivery to Clinical Perspectives.Nanomaterials (Basel, Switzerland) · 2021Review
- ADAM10 Plasma and CSF Levels Are Increased in Mild Alzheimer's Disease.International journal of molecular sciences · 2021Article
- Evaluation of the association between exosomal levels and female reproductive system and fertility outcome during aging: a systematic review protocol.Systematic reviews · 2019Article
- Circulating exosomes may identify biomarkers for cows at risk for metabolic dysfunction.Scientific reports · 2019Article
- Interferon tau-dependent and independent effects of the bovine conceptus on the endometrial transcriptome†.Biology of reproduction · 2019Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCell-to-cell communication between the blastocyst and endometrium is critical for implantation. In recent years, evidence has emerged from studies in humans and several other animal species that exosomes are secreted from the endometrium and trophoblast cells and may play an important role in cell-to-cell communication maternal-fetal interface during early pregnancy. Exosomes are stable extracellular lipid bilayer vesicles that encapsulate proteins, miRNAs, and mRNAs, with the ability to deliver their cargo to near and distant sites, altering cellular function(s). Furthermore, the exosomal cargo can be altered in response to environmental cues (e.g. hypoxia). The current study aims to develop an in vitro system to evaluate maternal-embryo interactions via exosomes (and exosomal cargo) produced by bovine endometrial stromal cells (ICAR) using hypoxia as a known stimulus associated with the release of exosomes and alterations to biological responses (e.g. cell proliferation).
methodsICAR cells cultured under 8 % O
resultsUnder hypoxic conditions (i.e. 1 % O
conclusionsIn summary, we have shown that a stimulus such as hypoxia can alter both the cellular function and exosome release of ICAR cells. Alterations to exosome release and exosomal content in response to stimuli may play a crucial role in maternal-fetal crosstalk and could also affect placental development.
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Registered trials
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