Evidence map›Paper›PMID 27829434›Full record

ArticleJournal of medical case reports2016

Human papillomavirus type 18 infection in a female renal allograft recipient: a case report.

Maksims Cistjakovs, Alina Sultanova, Olga Jermakova, Svetlana Chapenko, Baiba Lesina-Korne, Rafail Rozental, Dace Razeberga, Modra Murovska, Ieva Ziedina

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical case reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Maksims CistjakovsAugust Kirchenstein Institute of Microbiology and Virology, Riga Stradins University, Riga, Latvia. maksims.cistjakovs@rsu.lv.
Alina SultanovaAugust Kirchenstein Institute of Microbiology and Virology, Riga Stradins University, Riga, Latvia.
Olga JermakovaAugust Kirchenstein Institute of Microbiology and Virology, Riga Stradins University, Riga, Latvia.
Svetlana ChapenkoAugust Kirchenstein Institute of Microbiology and Virology, Riga Stradins University, Riga, Latvia.
Baiba Lesina-KorneGynecology and Maternity Unit, Pauls Stradins Clinical University Hospital, Riga, Latvia.
Rafail RozentalTransplant Research Laboratory, Riga Stradins University, Riga, Latvia.
Dace RazebergaGynecology and Maternity Unit, Pauls Stradins Clinical University Hospital, Riga, Latvia.
Modra MurovskaAugust Kirchenstein Institute of Microbiology and Virology, Riga Stradins University, Riga, Latvia.
Ieva ZiedinaTransplant Research Laboratory, Riga Stradins University, Riga, Latvia.
Riga Stradiņš University · LVPauls Stradiņš Clinical University Hospital · LV

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHuman papillomavirus type 18 is the second most common cause of cervical cancer and is found in 7 to 20 % of cases of cervical cancer. The oncogenic potential of high-risk human papillomavirus is associated with expression of early proteins E6 and E7. Due to long-term immunosuppressive therapy, renal transplant recipients have a higher risk of developing persistent human papillomavirus infection. CASE PRESENTATION: A 29-year-old white woman from Latvia with chronic focal segmental glomerulosclerosis received renal allograft transplantation and was prescribed immunosuppressive therapy with cyclosporine, prednisolone, and mycophenolate mofetil. Two weeks after renal transplantation, her cervical swab was positive for human papillomavirus consensus sequences. After 6 months, quantitative polymerase chain reaction showed a high viral load of 3,630,789 copies/10

conclusionsThis case report represents data which show that immunosuppressive therapy may increase the risk of developing persistent high-risk human papillomavirus infection with expression of E6 and E7 oncogenes in renal transplant recipients. However, even during this therapy the immune status of a recipient can improve and contribute to human papillomavirus viral load reduction. Spontaneous abortion can be considered a possible contributory factor in human papillomavirus clearance.

Indexed as

Abortion, SpontaneousAdultDNA-Binding ProteinsFemaleGlomerulosclerosis, Focal SegmentalHuman papillomavirus 18Human Papillomavirus DNA TestsHumansImmunosuppressive AgentsKidney TransplantationOncogene Proteins, ViralPapillomavirus InfectionsPostoperative ComplicationsPregnancyRNA, MessengerRNA, ViralDNA-Binding ProteinsE6 protein, Human papillomavirus type 18Immunosuppressive AgentsOncogene Proteins, ViralRNA, MessengerRNA, ViralCase reportHPV-18Immunosuppressive therapyRenal allograft transplantation

Identifiers

PMID27829434
PMCPMC5101687
OpenAlexW2554864012

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.