ArticleBMC complementary and alternative medicine2016
Hepatoprotective potential of Fagonia olivieri DC. against acetaminophen induced toxicity in rat.
Article in BMC complementary and alternative medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
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- A comparative study on the hepatoprotective effect of selenium-nanoparticles and dates flesh extract on carbon tetrachloride induced liver damage in albino rats.Anatomy & cell biology · 2023Article
- Chemico-Pharmacological Screening of the Methanol Extract ofMolecules (Basel, Switzerland) · 2022Article
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- The potential effect of phytochemicals and herbal plant remedies for treating drug-induced hepatotoxicity: a review.Molecular biology reports · 2021Review
- Petroselinum sativum protects HepG2 cells from cytotoxicity and oxidative stress induced by hydrogen peroxide.Molecular biology reports · 2020Article
- Biochemical profile and bioactive potential of thirteen wild folk medicinal plants from Balochistan, Pakistan.PloS one · 2020Article
- The Great Healing Potential Hidden in Plant Preparations of Antioxidant Properties: A Return to Nature?Oxidative medicine and cellular longevity · 2020Review
- Tempol Protects Against Acetaminophen Induced Acute Hepatotoxicity by Inhibiting Oxidative Stress and Apoptosis.Frontiers in physiology · 2019Article
- Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions.Redox biology · 2018Review
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- Euphorbia dracunculoides L. abrogates carbon tetrachloride induced liver and DNA damage in rats.BMC complementary and alternative medicine · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFagonia olivieri (DC) being used for the treatment of diabetes, cancer, fever and claimed to be effective in many other stress related disorders. In this study we have evaluated the F. olivieri whole methanol extract and its derived fractions for various in vitro and in vivo antioxidant studies.
methodsThe crude methanol extract of the whole plant of F. olivieri (FOM) and its derived fractions; n-hexane (FOH), chloroform (FOC), ethyl acetate (FOE), n-butanol (FOB) and aqueous (FOA) were evaluated for the total phenolic and flavonoid content and in vitro antioxidant abilities. The antioxidant effect of FOM was determined by acetaminophen-induced hepatotoxicity in Sprague-Dawley (Rattus novergicus) male rats. The methanol/fractions were also analysed by HPLC analysis for the presence of polyphenolics.
resultsThe total phenolic content of the samples ranged from 19.3 ± 0.529 to 106.2 ± 0.892 mg GAE/g extract while total flavonoid content 16.2 ± 0.881 to 50.1 ± 1.764 mg RTE/g extract, respectively. FOA showed highest radical scavenging activity for DPPH (IC
conclusionOur results showed that F. olivieri is a potential source of natural antioxidants, which justifies its use in folklore medicine.
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