ArticleCell reports2016
A Small Potassium Current in AgRP/NPY Neurons Regulates Feeding Behavior and Energy Metabolism.
Article in Cell reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 34 citations in OpenAlex.
- Serotonin neurons in the dorsal raphe control food-craving-like behavior during pregnancy in mice.Nature neuroscience · 2026Article
- The role of MICOS in modulating mitochondrial dynamics and structural changes in vulnerable regions of Alzheimer's Disease.bioRxiv : the preprint server for biology · 2025Article
- Cancer cell-extrinsic STING shapes immune-active microenvironment and predicts clinical outcome in gastric cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025Article
- Maternal supplementation with konjac glucomannan and κ-carrageenan promotes sow performance and benefits the gut barrier in offspring.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Article
- Article
- 27-Hydroxycholesterol acts on estrogen receptor α expressed by POMC neurons in the arcuate nucleus to modulate feeding behavior.Science advances · 2024Article
- GIRK2 potassium channels expressed by the AgRP neurons decrease adiposity and body weight in mice.PLoS biology · 2023Article
- Identification of a GABAergic neural circuit governing leptin signaling deficiency-induced obesity.eLife · 2023Article
- Increased intrinsic and synaptic excitability of hypothalamic POMC neurons underlies chronic stress-induced behavioral deficits.Molecular psychiatry · 2023Article
- The unique structural characteristics of the Kir 7.1 inward rectifier potassium channel: a novel player in energy homeostasis control.American journal of physiology. Cell physiology · 2023Review
- Fasting: From Physiology to Pathology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- Asprosin promotes feeding through SK channel-dependent activation of AgRP neurons.Science advances · 2023Article
- SK3 in POMC neurons plays a sexually dimorphic role in energy and glucose homeostasis.Cell & bioscience · 2022Article
- A D2 to D1 shift in dopaminergic inputs to midbrain 5-HT neurons causes anorexia in mice.Nature neuroscience · 2022Article
- Protein tyrosine phosphatase receptor δ serves as the orexigenic asprosin receptor.Cell metabolism · 2022Article
- 5-HT recruits distinct neurocircuits to inhibit hunger-driven and non-hunger-driven feeding.Molecular psychiatry · 2021Article
- Free-floating Immunostaining of Mouse Brains.Journal of visualized experiments : JoVE · 2021Article
- Reciprocal control of obesity and anxiety-depressive disorder via a GABA and serotonin neural circuit.Molecular psychiatry · 2021Article
- Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity.Molecular psychiatry · 2021Article
- A hindbrain dopaminergic neural circuit prevents weight gain by reinforcing food satiation.Science advances · 2021Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
Abstract
Neurons that co-express agouti-related peptide (AgRP) and neuropeptide Y (NPY) are indispensable for normal feeding behavior. Firing activities of AgRP/NPY neurons are dynamically regulated by energy status and coordinate appropriate feeding behavior to meet nutritional demands. However, intrinsic mechanisms that regulate AgRP/NPY neural activities during the fed-to-fasted transition are not fully understood. We found that AgRP/NPY neurons in satiated mice express high levels of the small-conductance calcium-activated potassium channel 3 (SK3) and are inhibited by SK3-mediated potassium currents; on the other hand, food deprivation suppresses SK3 expression in AgRP/NPY neurons, and the decreased SK3-mediated currents contribute to fasting-induced activation of these neurons. Genetic mutation of SK3 specifically in AgRP/NPY neurons leads to increased sensitivity to diet-induced obesity, associated with chronic hyperphagia and decreased energy expenditure. Our results identify SK3 as a key intrinsic mediator that coordinates nutritional status with AgRP/NPY neural activities and animals' feeding behavior and energy metabolism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.