ArticleCell reports2016
Touch Receptors Undergo Rapid Remodeling in Healthy Skin.
Article in Cell reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- A Comprehensive Review of GWASs of Human Hair Traits.The Journal of investigative dermatology · 2025Review
- A reconfigurable piezo-ionotropic polymer membrane for sustainable multi-resonance acoustic sensing.Nature communications · 2025Article
- Development and regeneration of Merkel cells.Current topics in developmental biology · 2025Review
- Revisiting a classical theory of sensory specificity: assessing consistency and stability of thermosensitive spots.Journal of neurophysiology · 2023Article
- Merkel Cell Polyomavirus T Antigen-Mediated Reprogramming in Adult Merkel Cell Progenitors.The Journal of investigative dermatology · 2023Article
- The Association of Multiple Sensory Impairment and Telomere Length: The Health ABC Study.The Laryngoscope · 2023Article
- Article
- Rapid structural remodeling of peripheral taste neurons is independent of taste cell turnover.PLoS biology · 2023Article
- Article
- Miswiring of Merkel cell and pruriceptive C fiber drives the itch-scratch cycle.Science translational medicine · 2022Article
- New insights into the mechanisms behind mechanical itch.Experimental dermatology · 2020Article
- Large-Scale Convergence of Receptor Cell Arrays Onto Afferent Terminal Arbors in the Lorenzinian Electroreceptors ofFrontiers in neuroanatomy · 2020Article
- A novel player in the field: Merkel disc in touch, itch and pain.Experimental dermatology · 2019Article
- Article
- Somatosensory innervation of the oral mucosa of adult and aging mice.Scientific reports · 2018Article
- Computation predicts rapidly adapting mechanotransduction currents cannot account for tactile encoding in Merkel cell-neurite complexes.PLoS computational biology · 2018Article
- Piezo2 channel-Merkel cell signaling modulates the conversion of touch to itch.Science (New York, N.Y.) · 2018Article
- Article
- A DISCRETE-EVENT SIMULATION APPROACH TO IDENTIFY RULES THAT GOVERN ARBOR REMODELING FOR BRANCHING CUTANEOUS AFFERENTS IN HAIRY SKIN.Proceedings of the ... Winter Simulation Conference. Winter Simulation Conference · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Sensory tissues exposed to the environment, such as skin, olfactory epithelia, and taste buds, continuously renew; therefore, peripheral neurons must have mechanisms to maintain appropriate innervation patterns. Although somatosensory neurons regenerate after injury, little is known about how these neurons cope with normal target organ changes. To elucidate neuronal plasticity in healthy skin, we analyzed the structure of Merkel-cell afferents, which are gentle touch receptors, during skin remodeling that accompanies mouse hair-follicle regeneration. The number of Merkel cells is reduced by 90% and axonal arbors are simplified during active hair growth. These structures rebound within just days. Computational modeling predicts that Merkel-cell changes are probabilistic, but myelinated branch stability depends on Merkel-cell inputs. Electrophysiology and behavior demonstrate that tactile responsiveness is less reliable during active growth than in resting skin. These results reveal that somatosensory neurons display structural plasticity at the cost of impairment in the reliability of encoding gentle touch.
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Registered trials
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