ArticleCell metabolism2016
Metabolic Signaling Drives IFN-γ.
Article in Cell metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Metabolic Reprogramming of T Cells by Dual UCP2 and IL-17 Blockade Enhances Immunity Against Pancreatic Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Metabolic control of innate-like T cells.Nature reviews. Immunology · 2026Review
- Dendritic cells: understanding ontogeny, subsets, functions, and their clinical applications.Molecular biomedicine · 2025Review
- Single-cell sequencing combined with spatial transcriptomics reveals that the IRF7 gene in M1 macrophages inhibits the occurrence of pancreatic cancer by regulating lipid metabolism-related mechanisms.Clinical and translational medicine · 2024Article
- Genetically engineering glycolysis in T cells increases their antitumor function.Journal for immunotherapy of cancer · 2024Article
- Hyperlipidaemia elicits an atypical, T helper 1-like CD4European heart journal open · 2023Article
- IFN-γ lowers tumor growth by increasing glycolysis and lactate production in a nitric oxide-dependent manner: implications for cancer immunotherapy.Frontiers in immunology · 2023Article
- Article
- Metabolic Modifications by Common Respiratory Viruses and Their Potential as New Antiviral Targets.Viruses · 2021Review
- LKB1-PTEN axis controls Th1 and Th17 cell differentiation via regulating mTORC1.Journal of molecular medicine (Berlin, Germany) · 2021Article
- Immune and Metabolic Dysregulated Coding and Non-coding RNAs Reveal Survival Association in Uterine Corpus Endometrial Carcinoma.Frontiers in genetics · 2021Article
- The immunologic changes during different phases of intestinal anastomotic healing.Journal of clinical laboratory analysis · 2020Review
- Lactation stage impacts the glycolytic function of bovine CD4Scientific reports · 2020Article
- Differential Reliance on Lipid Metabolism as a Salvage Pathway Underlies Functional Differences of T Cell Subsets in Poor Nutrient Environments.Cell reports · 2018Article
- The Peripheral and Intratumoral Immune Cell Landscape in Cancer Patients: A Proxy for Tumor Biology and a Tool for Outcome Prediction.Biomedicines · 2018Review
- Sirtuin1 Targeting Reverses Innate and Adaptive Immune Tolerance in Septic Mice.Journal of immunology research · 2018Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
IFN-γ is a critical inflammatory cytokine that is closely regulated to cellular metabolic status and requires high rates of glycolysis. It has now been shown that a key mechanism to link these pathways is through maintenance of acetyl-CoA and epigenetic regulation of the IFNG locus.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.