ArticlePloS one2016
High-Resolution Ultrasound-Switchable Fluorescence Imaging in Centimeter-Deep Tissue Phantoms with High Signal-To-Noise Ratio and High Sensitivity via Novel Contrast Agents.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Improving the spatial resolution and signal-to-noise ratio of ultrasound switchable fluorescence imaging.Journal of biophotonics · 2024Article
- Fast ICCD-based temperature modulated fluorescence tomography.Applied optics · 2023Article
- Noninvasive measurement of local temperature using ultrasound-switchable fluorescence.Biomedical optics express · 2023Article
- Article
- Size effect of liposomes on centimeter-deep ultrasound-switchable fluorescence imaging and ultrasound-controlled release.Journal of materials chemistry. B · 2022Article
- Interstitial fluid streaming in deep tissue induced by ultrasound momentum transfer for accelerating nanoagent transport and controlling its distribution.Physics in medicine and biology · 2022Article
- Recent advances in ultrasound-controlled fluorescence technology for deep tissue optical imaging.Journal of pharmaceutical analysis · 2022Review
- Improving sensitivity and imaging depth of ultrasound-switchable fluorescence via an EMCCD-gain-controlled system and a liposome-based contrast agent.Quantitative imaging in medicine and surgery · 2021Article
- Near-infrared temperature-switchable fluorescence nanoparticles.Quantitative imaging in medicine and surgery · 2021Article
- Article
- Radiolabeled PET/MRI Nanoparticles for Tumor Imaging.Journal of clinical medicine · 2019Review
- An ICCD camera-based time-domain ultrasound-switchable fluorescence imaging system.Scientific reports · 2019Article
- In vivo ultrasound-switchable fluorescence imaging.Scientific reports · 2019Article
- Newly-Engineered Materials for Bio-Imaging Technology: A Focus on the Hybrid System of Ultrasound and Fluorescence.Frontiers in bioengineering and biotechnology · 2019Review
- Feasibility study of high spatial resolution multimodality fluorescence tomography in ex vivo biological tissue.Applied optics · 2017Article
- The Mechanisms and Biomedical Applications of an NIR BODIPY-Based Switchable Fluorescent Probe.International journal of molecular sciences · 2017Article
- A Dual-Modality System for Both Multi-Color Ultrasound-Switchable Fluorescence and Ultrasound Imaging.International journal of molecular sciences · 2017Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
For many years, investigators have sought after high-resolution fluorescence imaging in centimeter-deep tissue because many interesting in vivo phenomena-such as the presence of immune system cells, tumor angiogenesis, and metastasis-may be located deep in tissue. Previously, we developed a new imaging technique to achieve high spatial resolution in sub-centimeter deep tissue phantoms named continuous-wave ultrasound-switchable fluorescence (CW-USF). The principle is to use a focused ultrasound wave to externally and locally switch on and off the fluorophore emission from a small volume (close to ultrasound focal volume). By making improvements in three aspects of this technique: excellent near-infrared USF contrast agents, a sensitive frequency-domain USF imaging system, and an effective signal processing algorithm, for the first time this study has achieved high spatial resolution (~ 900 μm) in 3-centimeter-deep tissue phantoms with high signal-to-noise ratio (SNR) and high sensitivity (3.4 picomoles of fluorophore in a volume of 68 nanoliters can be detected). We have achieved these results in both tissue-mimic phantoms and porcine muscle tissues. We have also demonstrated multi-color USF to image and distinguish two fluorophores with different wavelengths, which might be very useful for simultaneously imaging of multiple targets and observing their interactions in the future. This work has opened the door for future studies of high-resolution centimeter-deep tissue fluorescence imaging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.