ArticlePloS one2016
Hyperthermia Influences the Effects of Sodium Channel Blocking Drugs in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Arrhythmic events in Brugada syndrome patients induced by fever.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2020Pooled it
- Clinical Profile and Long-Term Follow-Up of Children with Brugada Syndrome.Pediatric cardiology · 2020Pooled it
- Temperature-Induced ICD Malfunction in a Patient With Brugada Syndrome.JACC. Case reports · 2025Article
- Article
- Hyperthermia Augments the H1-Histamine Receptor-Mediated Force in the Human Atrium.International journal of molecular sciences · 2025Article
- Characterization of novel arrhythmogenic patterns arising secondary to heterogeneous expression and activation of Nav1.8.Frontiers in cardiovascular medicine · 2025Article
- Fever, Syncope, and the Brugada Dilemma: Navigating the Complexities of ICD Decision-Making in an Atypical Presentation.Case reports in cardiology · 2025Article
- COVID-19 Vaccination-Induced Ventricular Fibrillation in an Afebrile Patient With Brugada Syndrome.Journal of Korean medical science · 2022Article
- Fever following Covid-19 vaccination in subjects with Brugada syndrome: Incidence and management.Journal of cardiovascular electrophysiology · 2022Article
- A Preclinical Study on Brugada Syndrome with a CACNB2 Variant Using Human Cardiomyocytes from Induced Pluripotent Stem Cells.International journal of molecular sciences · 2022Article
- Development and validation of a predictive model for new-onset atrial fibrillation in sepsis based on clinical risk factors.Frontiers in cardiovascular medicine · 2022Article
- Hyperthermia as a trigger for Takotsubo syndrome in a rat model.Frontiers in cardiovascular medicine · 2022Article
- TRPV1 activation and internalization is part of the LPS-induced inflammation in human iPSC-derived cardiomyocytes.Scientific reports · 2021Article
- Chloroquine and hydroxychloroquine provoke arrhythmias at concentrations higher than those clinically used to treat COVID-19: A simulation study.Clinical and translational science · 2021Article
- Block of Voltage-Gated Sodium Channels by Atomoxetine in a State- and Use-dependent Manner.Frontiers in pharmacology · 2021Article
- The association between body temperature and electrocardiographic parameters in normothermic healthy volunteers.Pacing and clinical electrophysiology : PACE · 2021Article
- Review
- Cardiac arrhythmias in patients with COVID-19.Journal of arrhythmia · 2020Review
- Biophysical Characterization of Epigallocatechin-3-Gallate Effect on the Cardiac Sodium Channel NaMolecules (Basel, Switzerland) · 2020Article
- Serum of patients with acute myocardial infarction prevents inflammation in iPSC-cardiomyocytes.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
18 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionFever can increase the susceptibility to supraventricular and ventricular arrhythmias, in which sodium channel dysfunction has been implicated. Whether fever influences the efficacy of sodium channel blocking drugs is unknown. The current study was designed to investigate the temperature dependent effects of distinct sodium channel blocking drugs on the sodium currents in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). METHODS AND
resultshiPSC-CMs were generated from human skin fibroblasts of a healthy donor. The peak and late sodium currents (INa), steady-state activation, inactivation and recovery from inactivation of INa in hiPSC-CMs were analyzed using the whole-cell patch clamp technique. The effects of different concentrations of the antiarrhythmic drugs flecainide, lidocaine, ajmaline and the antianginal drug ranolazine on INa were tested at 36°C and 40°C. Increasing the temperature of the bath solution from 36°C to 40°C enhanced the inhibition of peak INa but reduced the inhibition of late INa by flecainide and lidocaine. By contrast, increasing the temperature reduced the effect of ajmaline and ranolazine on the peak INa but not late INa. None of the tested drugs showed temperature-dependent effects on the steady-state activation and inactivation as well as on the recovery from inactivation of INa in hiPSC-CMs.
conclusionsTemperature variation from the physiological to the febrile range apparently influences the effects of sodium channel blockers on the sodium currents. This may influence their antiarrhythmic efficacy in patients suffering from fever.
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