Evidence map›Paper›PMID 27828989›Full record

ArticlePloS one2016

Predicted Enhanced Human Propensity of Current Avian-Like H1N1 Swine Influenza Virus from China.

Veljko Veljkovic, Nevena Veljkovic, Slobodan Paessler, Marco Goeijenbier, Vladimir Perovic, Sanja Glisic, Claude P Muller

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 84% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 4 countries.

Veljko VeljkovicCenter for Multidisciplinary Research, Institute of Nuclear Sciences Vinca, University of Belgrade, Mihajla Petrovica 12-14, 11001 Belgrade, Serbia.
Nevena VeljkovicCenter for Multidisciplinary Research, Institute of Nuclear Sciences Vinca, University of Belgrade, Mihajla Petrovica 12-14, 11001 Belgrade, Serbia.
Slobodan PaesslerDepartment of Pathology, Galveston National Laboratory, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX, United States of America.
Marco GoeijenbierDepartment of Viroscience, Erasmus Universitair Medisch Centrum Rotterdam, Rotterdam, Netherlands.
Vladimir PerovicCenter for Multidisciplinary Research, Institute of Nuclear Sciences Vinca, University of Belgrade, Mihajla Petrovica 12-14, 11001 Belgrade, Serbia.
Sanja GlisicCenter for Multidisciplinary Research, Institute of Nuclear Sciences Vinca, University of Belgrade, Mihajla Petrovica 12-14, 11001 Belgrade, Serbia.
Claude P MullerDepartment of Infection and Immunity, Luxembourg Institute of Health, 29, rue Henri Koch, L-4534 Esch-Alzette, Grand-Duchy of Luxembourg.
University of Belgrade · RSErasmus University Rotterdam · NLLuxembourg Institute of Health · LUThe University of Texas Medical Branch at Galveston · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Influenza A virus (IAV) subtypes against which little or no pre-existing immunity exists in humans represent a serious threat to global public health. Monitoring of IAV in animal hosts is essential for early and rapid detection of potential pandemic IAV strains to prevent their spread. Recently, the increased pandemic potential of the avian-like swine H1N1 IAV A/swine/Guangdong/104/2013 has been suggested. The virus is infectious in humans and the general population seems to lack neutralizing antibodies against this virus. Here we present an in silico analysis that shows a strong human propensity of this swine virus further confirming its pandemic potential. We suggest mutations which would further enhance its human propensity. We also propose conserved antigenic determinants which could serve as a component of a prepandemic vaccine. The bioinformatics tool, which can be used to further monitor the evolution of swine influenza viruses towards a pandemic virus, are described here and are made publically available (http://www.vin.bg.ac.rs/180/tools/iav_mon.php; http://www.biomedprotection.com/iav_mon.php).

Indexed as

AnimalsAntibodies, NeutralizingAntibodies, ViralAntigens, ViralBird DiseasesBirdsChinaComputational BiologyConserved SequenceEuropeHemagglutinin Glycoproteins, Influenza VirusHumansInfluenza A Virus, H1N1 SubtypeInfluenza VaccinesInternetMutationAntibodies, NeutralizingAntibodies, ViralAntigens, ViralH1N1 virus hemagglutininHemagglutinin Glycoproteins, Influenza VirusInfluenza Vaccines

Identifiers

PMID27828989
PMCPMC5102363
OpenAlexW2552378418

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.