ArticlePloS one2016
Discovery and Partial Genomic Characterisation of a Novel Nidovirus Associated with Respiratory Disease in Wild Shingleback Lizards (Tiliqua rugosa).
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 51 citations in OpenAlex.
- Evolutionarily divergent nidovirus with an exceptionally large genome identified in Pacific oysters undergoing mass mortality.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Identifying Infectious Agents in Snakes (Boidae and Pythonidae) with and Without Respiratory Disease.Animals : an open access journal from MDPI · 2025Article
- Seasonal contact and migration structure mass epidemics and inform outbreak preparedness in a vulnerable marine mammal.Proceedings. Biological sciences · 2025Article
- Identification and Characterization of Novel Serpentoviruses in Viperid and Elapid Snakes.Viruses · 2024Article
- Article
- Serpentoviruses Exhibit Diverse Organization and ORF Composition with Evidence of Recombination.Viruses · 2024Article
- Review
- In Vitro Characterization and Antiviral Susceptibility of Ophidian Serpentoviruses.Microorganisms · 2023Article
- Divergent Serpentoviruses in Free-Ranging Invasive Pythons and Native Colubrids in Southern Florida, United States.Viruses · 2022Article
- Revealing the uncharacterised diversity of amphibian and reptile viruses.ISME communications · 2022Article
- Editorial: Emerging infections and diseases of herpetofauna.Frontiers in veterinary science · 2022Article
- Nidoviruses in Reptiles: A Review.Frontiers in veterinary science · 2021Review
- Genomic Insights Into the Pathogenicity of a Novel Biofilm-FormingFrontiers in microbiology · 2021Article
- The taxonomy, host range and pathogenicity of coronaviruses and other viruses in theAnimal diseases · 2021Review
- Serpentovirus (Nidovirus) and Orthoreovirus Coinfection in Captive Veiled Chameleons (Viruses · 2020Article
- Serpentoviruses: More than Respiratory Pathogens.Journal of virology · 2020Article
- A case report of reptile-associated nidovirus (serpentovirus) in a ball python (Python regius) in Taiwan.The Journal of veterinary medical science · 2020Article
- Investigations into the presence of nidoviruses in pythons.Virology journal · 2020Article
- Article
- Viral Diversity of Microbats within the South West Botanical Province of Western Australia.Viruses · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A respiratory disease syndrome has been observed in large numbers of wild shingleback lizards (Tiliqua rugosa) admitted to wildlife care facilities in the Perth metropolitan region of Western Australia. Mortality rates are reportedly high without supportive treatment and care. Here we used next generation sequencing techniques to screen affected and unaffected individuals admitted to Kanyana Wildlife Rehabilitation Centre in Perth between April and December 2015, with the resultant discovery of a novel nidovirus significantly associated with cases of respiratory disease according to a case definition based on clinical signs. Interestingly this virus was also found in 12% of apparently healthy individuals, which may reflect testing during the incubation period or a carrier status, or it may be that this agent is not causative in the disease process. This is the first report of a nidovirus in lizards globally. In addition to detection of this virus, characterisation of a 23,832 nt segment of the viral genome revealed the presence of characteristic nidoviral genomic elements providing phylogenetic support for the inclusion of this virus in a novel genus alongside Ball Python nidovirus, within the Torovirinae sub-family of the Coronaviridae. This study highlights the importance of next generation sequencing technologies to detect and describe emerging infectious diseases in wildlife species, as well as the importance of rehabilitation centres to enhance early detection mechanisms through passive and targeted health surveillance. Further development of diagnostic tools from these findings will aid in detection and control of this agent across Australia, and potentially in wild lizard populations globally.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.