Evidence map›Paper›PMID 27828877›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2017

Brief Report: Elevated Red Cell Distribution Width Identifies Elevated Cardiovascular Disease Risk in Patients With HIV Infection.

Sadeer G Al-Kindi, Chang H Kim, Stephen R Morris, Michael L Freeman, Nicholas T Funderburg, Benigno Rodriguez, Grace A McComsey, Jarrod E Dalton, Daniel I Simon, Michael M Lederman and 2 more

Abstract read
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Lights and Shadows of Microbiota Modulation and Cardiovascular Risk in HIV Patients.International journal of environmental research and public health · 2021
    Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Observational
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Sadeer G Al-Kindi*Harrington Heart & Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH; †Division of Infectious Diseases and HIV Medicine, Department of Medicine, Center for AIDS Research, Case Western Reserve University/University Hospitals Cleveland Medical Center, Cleveland, OH; ‡Division of Medical Laboratory Science, School of Health and Rehabilitation Sciences, Ohio State University, Columbus, OH; §School of Medicine, Case Western Reserve University, Cleveland, OH; and ‖Section of Health Outcomes Research and Clinical Epidemiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH.
Chang H Kim
Stephen R Morris
Michael L Freeman
Nicholas T Funderburg
Benigno Rodriguez
Grace A McComsey
Jarrod E Dalton
Daniel I Simon
Michael M Lederman
Chris T Longenecker
David A Zidar
University Hospitals of Cleveland · USCase Western Reserve University · USThe Ohio State University · US

Funding

Validation, CLIA and Qualification (VQC): Enhancing the RS ratio as a tool for AIDS Clinical Trial Group (ACTG) tuberculosis trialsUM1AI106701 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Grace M Aldrovandi · 2014 to 2026
$116.8M
WG3: HIV, Co-infections and Co-morbiditiesP30AI036219 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI John Christian Tilton · 1994 to 2026
$50.0M
Clinical and Translational Science Collaborative of ClevelandKL2TR000440 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$11.1M
Pericardial fat, inflammation, and structural heart disease in HIVK23HL123341 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI LONGENECKER, CHRIS TODD · 2014 to 2018
$885k
NCATS NIH HHS KL2 TR000440NHLBI NIH HHS K23 HL123341NIAID NIH HHS P30 AI036219NIAID NIH HHS UM1 AI106701
6 · The paper itself

Abstract

Red cell distribution width (RDW) is linked to cardiovascular risk in the general population, an association that might be driven by inflammation. Whether this relationship holds for patients with HIV infection has not been previously studied. Using a large clinical registry, we show that elevated RDW (>14.5%) is independently associated with increased risk of coronary artery disease {odds ratio [OR] 1.39 [95% confidence interval (CI): 1.25 to 1.55]}, peripheral vascular disease [OR 1.41 (95% CI: 1.29 to 1.53)], myocardial infarction [1.43 (95% CI: 1.25 to 1.63)], heart failure [OR 2.23 (95% CI: 1.99 to 2.49)], and atrial fibrillation [OR 1.96 (95% CI: 1.64 to 2.33)]. In conclusion, in the context of the inflammatory milieu that accompanies HIV infection, RDW remains a powerful marker of cardiovascular disease.

Indexed as

Erythrocyte IndicesAdolescentAdultAgedBiomarkersCardiovascular DiseasesCohort StudiesFemaleHIV InfectionsHumansMaleMiddle AgedRisk AssessmentYoung AdultBiomarkers

Identifiers

PMID27828877
PMCPMC5303143
OpenAlexW2555037053

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.