Evidence map›Paper›PMID 27828801›Full record

ReviewCurrent opinion in HIV and AIDS2017

Human papillomavirus-associated anal and cervical cancers in HIV-infected individuals: incidence and prevention in the antiretroviral therapy era.

Joel M Palefsky

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Current opinion in HIV and AIDS, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04270773 (Immunogenicity and Safety of a 9-valent Human Papillomavirus Vaccine in HIV-positive Women.), which is not on this map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04270773 phase4unknown statusnot on this mapstarted 2020, after this paper: background citation

Immunogenicity and Safety of a 9-valent Human Papillomavirus Vaccine in HIV-positive Women.

TypeinterventionalSponsorUniversity Hospital Virgen de las NievesRan2020 to 2024Enrolled158ConditionsHIV Infections, HPV InfectionArmsHuman Papillomavirus 9-valent Vaccine, Recombinant
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 63 citations in OpenAlex.

  1. Construct validity and responsiveness of a health-related symptom index for persons either treated or monitored for anal high-grade squamous intraepithelial lesions (HSIL): AMC-A01/-A03.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023
    Trial
  2. Review
  3. Review
  4. Cancer in People with HIV.Infectious disease clinics of North America · 2024
    Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Malignancy and viral infections in Sub-Saharan Africa: A review.Frontiers in virology (Lausanne, Switzerland) · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Anal High-risk HPV and Liquid-based Cytology of Immunocompetent Brazilian Women with Genital High-risk HPV.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2022
    Observational
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Joel M PalefskyUniversity of California, San Francisco, San Francisco, California, USA.
University of California, San Francisco · US

Funding

Consortium for Advancing Management and Prevention of Cancer in People with HIVUM1CA121947 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Joseph A. Sparano · 2015 to 2026
$253.7M
University of Southern CaliforniaU01CA121947 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KROWN, SUSAN E · 2006 to 2014
$54.7M
(PQ4) Anal HPV infection and anal HSIL among HIV-infected MSM aged 50+ yearsR01CA206477 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PALEFSKY, JOEL MICHAEL · 2016 to 2021
$3.4M
NCI NIH HHS R01 CA206477NCI NIH HHS U01 CA121947NCI NIH HHS UM1 CA121947
6 · The paper itself

Abstract

purpose of reviewThe incidence of human papillomavirus (HPV)-related cancers has increased (anal cancer) or not declined (cervical cancer) since the introduction of antiretroviral therapy (ART). This article reviews recent data on incidence and prevention efforts for HPV-related cancers in the ART era. RECENT

findingsART may confer some benefit with respect to reducing the risk of anal high-grade squamous intraepithelial lesion and cancer, but the degree of that benefit appears to be limited. The prevalence of anal HPV infection, anal high-grade squamous intraepithelial lesion, and anal cancer remain high among individuals on effective ART. The incidence of cervical cancer is high among HIV-infected women, particularly in countries wherein there are no organized cervical cancer prevention programmes. Efforts are in progress to define optimal screen-and-treat cervical cancer prevention programmes in different clinical settings and to define the efficacy of secondary prevention programmes for prevention of anal cancer. SUMMARY: HPV-related cancers are likely to remain an important problem in HIV-infected men and women for the foreseeable future, even among those on effective ART.

Indexed as

Anus NeoplasmsFemaleHIV InfectionsHumansIncidenceMalePapillomavirus InfectionsUterine Cervical Neoplasms

Identifiers

PMID27828801
PMCPMC5292043
OpenAlexW2553093524

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.