Evidence map›Paper›PMID 27827955›Full record

ArticleInternational journal of molecular sciences2016

A Novel Role of Dickkopf-Related Protein 3 in Macropinocytosis in Human Bladder Cancer T24 Cells.

Nonoka Tsujimura, Nami O Yamada, Yuki Kuranaga, Minami Kumazaki, Haruka Shinohara, Kohei Taniguchi, Yukihiro Akao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nonoka TsujimuraUnited Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu-city, Gifu 501-1194, Japan. nono.pi306@gmail.com.
Nami O YamadaUnited Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu-city, Gifu 501-1194, Japan. nyamada@gifu-u.ac.jp.
Yuki KuranagaUnited Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu-city, Gifu 501-1194, Japan. v3501001@edu.gifu-u.ac.jp.
Minami KumazakiUnited Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu-city, Gifu 501-1194, Japan. t3501001@edu.gifu-u.ac.jp.
Haruka ShinoharaUnited Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu-city, Gifu 501-1194, Japan. harukashinohara313@gmail.com.
Kohei TaniguchiUnited Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu-city, Gifu 501-1194, Japan. sur144@osaka-med.ac.jp.
Yukihiro AkaoUnited Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu-city, Gifu 501-1194, Japan. yakao@gifu-u.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dickkopf-related protein 3 (Dkk-3) is a potential tumor suppressor reported in various cancer entities. However, we found that Dkk-3 was exceptionally upregulated in bladder cancer T24 cells. To validate the biological role of Dkk-3 other than a tumor suppressor, we examined the function of Dkk-3 in T24 cells. Gene silencing of Dkk-3 inhibited cell growth through inducing G₀/G₁ cell-cycle arrest. Furthermore, Dkk-3 knock-down caused macropinocytosis accompanied by autophagy, which were canceled in part by their inhibitors 5-(

Indexed as

Gene Expression Regulation, NeoplasticAdaptor Proteins, Signal TransducingAdenineAmilorideAutophagyCell Line, TumorCell ProliferationChemokinesEpithelial CellsG1 Phase Cell Cycle CheckpointsGene SilencingHumansIntercellular Signaling Peptides and ProteinsLysosomal-Associated Membrane Protein 1Lysosomal Membrane ProteinsMAP Kinase Kinase 43-methyladenineAdaptor Proteins, Signal TransducingAdenineAmilorideChemokinesDKK3 protein, humanethylisopropylamilorideIntercellular Signaling Peptides and ProteinsLAMP1 protein, humanLysosomal-Associated Membrane Protein 1Lysosomal Membrane ProteinsMAPK1 protein, humanMAP Kinase Kinase 4MicroRNAsMIRN92 microRNA, humanMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3p38 Mitogen-Activated Protein KinasesRAB5C protein, humanrab5 GTP-Binding Proteinsrac1 GTP-Binding ProteinRAC1 protein, humanRNA, Small InterferingautophagyDickkopf-3macropinocytosisnutrition

Identifiers

PMID27827955
PMCPMC5133846

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.